Osteoporosis is a major bone disease that connotes the risk of fragility fractures resulting from alterations to bone
quantity and/or quality to mechanical competence. Bone strength arises from both bone quantity and quality. Assessment
of bone quality and bone quantity is important for prediction of fracture risk. In spite of the two factors contribute to
maintain the bone strength, only one factor, bone mineral density is used to determine the bone strength in the current
diagnosis of osteoporosis. On the other hand, there is no practical method to measure chemical composition of bone
tissue including hydroxyapatite and collagen non-invasively. Raman spectroscopy is a powerful technique to analyze
chemical composition and material properties of bone matrix non-invasively. Here we demonstrated Raman
spectroscopic analysis of the bone matrix in osteoporosis model rat. Ovariectomized (OVX) rat was made and the
decalcified sections of tibias were analyzed by a Raman microscope. In the results, Raman bands of typical collagen
appeared in the obtained spectra. Although the typical mineral bands at 960 cm-1 (Phosphate) was absent due to
decalcified processing, we found that Raman peak intensities of amide I and C-C stretching bands were significantly
different between OVX and sham-operated specimens. These differences on the Raman spectra were statistically
compared by multivariate analyses, principal component analysis (PCA) and liner discrimination analysis (LDA). Our
analyses suggest that amide I and C-C stretching bands can be related to stability of bone matrix which reflects bone
quality.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.