Dr. Yusuke Oshima Profile

Dr. Yusuke Oshima

Associate Professor at Univ of Toyama

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Author

Publications (25)

Proceedings Article | 12 March 2024 Presentation + Paper

Intraoperative tissue identification for gastrointestinal disorder by Raman spectroscopy and machine learning

Yusuke Oshima, Katsuhiro Ogawa, Haruto Fumuro, Takashi Katagiri, Masafumi Inomata

Proceedings Volume 12839, 1283903 (2024) https://doi.org/10.1117/12.3005335

KEYWORDS: Raman spectroscopy, Surgery, Diseases and disorders, Machine learning, Laparoscopy, Tissues, Spectroscopy, In vivo imaging, Resection, Optical fibers

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Proceedings Article | 15 March 2023 Poster + Paper

Pathological analysis of degenerative changes in humeral osteoarthritis using Raman spectroscopy

Ryuji Asaoka, Hiroshi Kiyomatsu, Akihiro Jono, Masaki Takao, Takashi Katagiri, Yusuke Oshima

Proceedings Volume 12363, 1236309 (2023) https://doi.org/10.1117/12.2650088

KEYWORDS: Raman spectroscopy, Cartilage, Principal component analysis, Collagen, Tissues, Head, Resection, Matrices, Surgery, Statistical analysis

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Proceedings Article | 6 March 2023 Presentation + Paper

Optical biopsy technique for detection of aganglionosis in Hirschsprung disease by Raman spectroscopy combined with deep learning

Yuki Matsumoto, Katsuhiro Ogawa, Kai Tamura, Rena Yagi, Shun Onishi, Satoshi Ieiri, Tsuyoshi Etoh, Masafumi Inomata, Takashi Katagiri, Yusuke Oshima

Proceedings Volume 12368, 123680B (2023) https://doi.org/10.1117/12.2650175

KEYWORDS: Raman spectroscopy, Biopsy, Diseases and disorders, Deep learning, Surgery, Tissue optics, Optical design, Biomedical optics, Resection

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SPIE Journal Paper | 10 November 2022 Open Access

Prognostic potential and pathological validation of a diagnostic application using Raman spectroscopy in the characterization of degenerative changes in the cartilage of the humeral head

Ryuji Asaoka, Hiroshi Kiyomatsu, Hiromasa Miura, Akihiro Jono, Tomofumi Kinoshita, Masaki Takao, Takashi Katagiri, Yusuke Oshima

JBO, Vol. 27, Issue 11, 115002, (November 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.11.115002

KEYWORDS: Raman spectroscopy, Cartilage, Collagen, Diagnostics, Spectroscopy, Head, Principal component analysis, Tissues, Proteins, Statistical analysis

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SignificanceRaman spectroscopy is a well-established analytical method in the fields of chemistry, industry, biology, pharmaceutics, and medicine. Previous studies have investigated optical imaging and Raman spectroscopy for osteoarthritis (OA) diagnosis in weight-bearing joints such as hip and knee joints. However, to realize early diagnosis or a curable treatment, it is still challenging to understand the correlations with intrinsic factors or patients’ background.AimTo elucidate the correlation between the Raman spectral features and pathological variations of human shoulder joint cartilage.ApproachOsteoarthritic cartilage specimens excised from the humeral heads of 14 patients who underwent shoulder arthroplasty were assessed by a confocal Raman microscope and histological staining. The Raman spectroscopic dataset of degenerative cartilage was further analyzed by principal component analysis and hierarchical cluster analysis.ResultsMultivariate association of the Raman spectral data generated three major clusters. The first cluster of patients shows a relatively high Raman intensity of collagen. The second cluster displays relatively low Raman intensities of proteoglycans (PGs) and glycosaminoglycans (GAGs), whereas the third cluster shows relatively high Raman intensities of PGs and GAGs. The reduced PGs and GAGs are typical changes in OA cartilage, which have been confirmed by safranin–O staining. In contrast, the increased Raman intensities of collagen, PGs, and GAGs may reflect the instability of the cartilage matrix structure in OA patients.ConclusionsThe results obtained confirm the correlation between the Raman spectral features and pathological variations of human shoulder joint cartilage. Unsupervised machine learning methods successfully yielded a clinically meaningful classification between the shoulder OA patients. This approach not only has potential to confirm severity of cartilage defects but also to determine the origin of an individual’s OA by evaluating the cartilage quality.

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Proceedings Article | 7 March 2022 Presentation

Mid-infrared hollow fiber couplers

Masanori Kato, Yuji Matsuura, Yusuke Oshima, Takashi Katagiri

Proceedings Volume PC11953, PC119530B (2022) https://doi.org/10.1117/12.2615546

KEYWORDS: Fiber couplers, Mid-IR, Fiber lasers

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Proceedings Article | 11 March 2020 Presentation

Detection of nervous system in gastrointestinal wall using Raman spectroscopy (Conference Presentation)

Katsuhiro Ogawa, Yusuke Oshima, Takahiro Hiratsuka, Tomonori Akagi, Kosuke Suzuki, Tomotaka Shibata, Yoshitake Ueda, Manabu Tojigamori, Hidefumi Shiroshita, Tsuyoshi Etoh, Masafumi Inomata

Proceedings Volume 11247, 1124708 (2020) https://doi.org/10.1117/12.2545358

KEYWORDS: Nervous system, Raman spectroscopy, Diagnostics, Blood circulation, Tissues, Natural surfaces, Microscopes, Principal component analysis

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Proceedings Article | 19 February 2020 Presentation + Paper

Development of photodynamic diagnosis and therapy for peritoneal dissemination using NIR fiber laser system

Y. Shirasaka, Y. Oshima, T. Inoue, Y. Maeda, T. Hiratsuka, T. Akagi, K. Suzuki, T. Shibata, Y. Ueda, M. Tojigamori, H. Shiroshita, T. Etoh, N. Shiraishi, M. Inomata

Proceedings Volume 11220, 112200A (2020) https://doi.org/10.1117/12.2546958

KEYWORDS: Photodynamic therapy, Cancer, Near infrared, Laser therapeutics, Fiber lasers, Laser systems engineering, Oncology, Bladder cancer, Tissues, Safety

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Proceedings Article | 24 April 2018 Paper

Characterization of cancer metastasis in model mice by multiphoton microscopy and Raman spectroscopy

Yusuke Oshima, Shigehiro Koga, Hiromi Yamamoto, Yuji Watanabe

Proceedings Volume 10711, 107110X (2018) https://doi.org/10.1117/12.2317041

KEYWORDS: Raman spectroscopy, Cancer, Tumors, Tissues, Tumor growth modeling, Multiphoton microscopy, Diagnostics, Animal model studies, In vivo imaging, Natural surfaces

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Proceedings Article | 22 February 2018 Presentation + Paper

Raman spectroscopic analysis for gastric and colorectal cancer in surgical treatment toward molecular-guided surgery

Shigehiro Koga, Yuji Watanabe, Yusuke Oshima

Proceedings Volume 10478, 1047806 (2018) https://doi.org/10.1117/12.2291435

KEYWORDS: Raman spectroscopy, Cancer, Colorectal cancer, Surgery, Tissues, Spectroscopy, Tumors, Oncology, Light scattering, Imaging spectroscopy

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Proceedings Article | 20 February 2018 Presentation + Paper

Evaluation of degenerative changes in articular cartilage of osteoarthritis by Raman spectroscopy

Yusuke Oshima, Yasumitsu Ishimaru, Hiroshi Kiyomatsu, Kazunori Hino, Hiromasa Miura

Proceedings Volume 10497, 104971A (2018) https://doi.org/10.1117/12.2291383

KEYWORDS: Cartilage, Raman spectroscopy, Tissues, Surgery, Collagen, Natural surfaces, X-rays, Spectroscopy, Bone, Diagnostics

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Proceedings Article | 20 February 2018 Paper

Detection of changes in bone quality of osteoporotic model induced by sciatic nerve resection by using Raman spectroscopy

Yasumitsu Ishimaru, Yusuke Oshima, Yuuki Imai, Tadahiro Iimura, Sota Takanezawa, Kazunori Hino, Hiromasa Miura

Proceedings Volume 10497, 1049722 (2018) https://doi.org/10.1117/12.2291258

KEYWORDS: Bone, Raman spectroscopy, Minerals, Nerve, Surgery, Medicine, Analytical research, Microscopes, Animal model studies, Computed tomography

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Proceedings Article | 18 April 2017 Paper

Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy

Yasumitsu Ishimaru, Yusuke Oshima, Yuuki Imai, Tadahiro Iimura, Sota Takanezawa, Kazunori Hino, Hiromasa Miura

Proceedings Volume 10251, 102511D (2017) https://doi.org/10.1117/12.2274980

KEYWORDS: Minerals, Surgery, Animal model studies, Carbonates, Medicine, Analytical research, Biological research, Bone, Raman spectroscopy, Nerve, Collagen

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Proceedings Article | 18 April 2017 Paper

Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy

Yusuke Oshima, Mayu Akehi, Hiroshi Kiyomatsu, Hiromasa Miura

Proceedings Volume 10251, 1025108 (2017) https://doi.org/10.1117/12.2275047

KEYWORDS: Spectroscopy, Molecular spectroscopy, Bone, Animal model studies, Tissues, Principal component analysis, Surgery, Cartilage, Raman spectroscopy, Collagen

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Proceedings Article | 17 February 2017 Presentation + Paper

Raman spectroscopy for cancer detection and characterization in metastasis models

Shigehiro Koga, Yusuke Oshima, Mitsunori Sato, Kei Ishimaru, Motohira Yoshida, Yuji Yamamoto, Yusuke Matsuno, Yuji Watanabe

Proceedings Volume 10060, 100600O (2017) https://doi.org/10.1117/12.2250748

KEYWORDS: Raman spectroscopy, Cancer, Light scattering, Tumor growth modeling, Diagnostics, Tissue optics, Tissues, In vitro testing, In vivo imaging, Luminescence, Tumors, Near infrared

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Proceedings Article | 14 February 2017 Presentation + Paper

Label-free characterization of articular cartilage in osteoarthritis model mice by Raman spectroscopy

Yusuke Oshima, Mayu Akehi, Hiroshi Kiyomatsu, Hiromasa Miura

Proceedings Volume 10054, 1005406 (2017) https://doi.org/10.1117/12.2250673

KEYWORDS: X-rays, Magnetic resonance imaging, Molecular spectroscopy, Surgery, Principal component analysis, Bone

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Proceedings Article | 12 March 2015 Paper

In vivo detection of cancer cells with immunoconjugated fluorescent probes by macro zoom microscopy and two-photon microscopy

Shigehiro Koga, Yusuke Oshima, Atsuhiko Hikita, Koichi Sato, Motohira Yoshida, Yuji Yamamoto, Tadahiro Iimura, Yuji Watanabe, Takeshi Imamura

Proceedings Volume 9339, 93390J (2015) https://doi.org/10.1117/12.2079092

KEYWORDS: Cancer, Luminescence, In vivo imaging, Tumors, Near infrared, Two photon excitation microscopy, Microscopy, Zoom lenses, Green fluorescent protein, Microscopes

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Proceedings Article | 26 February 2015 Paper

Changes in chemical composition of bone matrix in ovariectomized (OVX) rats detected by Raman spectroscopy and multivariate analysis

Yusuke Oshima, Tadahiro Iimura, Takashi Saitou, Takeshi Imamura

Proceedings Volume 9303, 93033S (2015) https://doi.org/10.1117/12.2078787

KEYWORDS: Bone, Raman spectroscopy, Chemical analysis, Principal component analysis, Minerals, Collagen, Microscopes, Statistical analysis, Tissues, Proteins

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Proceedings Article | 4 March 2014 Paper

In vivo imaging of spinal cord in contusion injury model mice by multi-photon microscopy

Y. Oshima, H. Horiuchi, T. Ogata, A. Hikita, H. Miura, T. Imamura

Proceedings Volume 8947, 894708 (2014) https://doi.org/10.1117/12.2041042

KEYWORDS: Injuries, Spinal cord, Axons, Microscopy, In vivo imaging, Multiphoton microscopy, Luminescence, Tissues, Laser ablation, Optical imaging

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Proceedings Article | 3 February 2012 Paper

Multimodal light-sheet microscopy for fluorescence live imaging

Y. Oshima, H. Kajiura-Kobayashi, S. Nonaka

Proceedings Volume 8227, 82271H (2012) https://doi.org/10.1117/12.907937

KEYWORDS: Luminescence, Microscopy, Imaging systems, Two photon imaging, Multiphoton microscopy, Multiphoton fluorescence microscopy, Two photon excitation microscopy, Near infrared, Fiber lasers, Raman spectroscopy

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Proceedings Article | 12 February 2010 Paper

In situ cell cycle phase determination using Raman spectroscopy

Yusuke Oshima, Tatsuji Takenaka, Hidetoshi Sato, Chie Furihata

Proceedings Volume 7560, 756008 (2010) https://doi.org/10.1117/12.840593

KEYWORDS: Raman spectroscopy, Flow cytometry, Biological research, Imaging spectroscopy, Chemical analysis, Proteins, Luminescence, Lung cancer, Near infrared, Biomedical optics

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SPIE Journal Paper | 1 January 2010 Open Access

Discrimination analysis of human lung cancer cells associated with histological type and malignancy using Raman spectroscopy

Yusuke Oshima, Hideyuki Shinzawa, Tatsuji Takenaka, Chie Furihata, Hidetoshi Sato

JBO, Vol. 15, Issue 01, 017009, (January 2010) https://doi.org/10.1117/12.10.1117/1.3316296

KEYWORDS: Raman spectroscopy, Cancer, Lung cancer, Principal component analysis, Proteins, Tissues, Tumor growth modeling, Biological research, Lung, Spectroscopy

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Proceedings Article | 24 February 2009 Paper

Verifying of endocrine disruptor chemical affect to the mouse testes: can raman spectroscopy support histology study?

Bibin Andriana, Yusuke Oshima, Sota Takanezawa, Tat Tay, Catherine Linda Rosawati Soeratman, Mohammad Alam, Hiroki Mitsuoka, Xiao Zhu, Toshiaki Suzuki, Yuko Yamamoto, Naoki Tsunekawa, Yoshiakira Kanai, Masamichi Kurohmaru, Hidetoshi Sato

Proceedings Volume 7167, 71670Y (2009) https://doi.org/10.1117/12.808700

KEYWORDS: Raman spectroscopy, Collagen, Testis, Tissue optics, Tissues, Cell death, Glasses, Confocal microscopy, Analytical research, Microscopy

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Proceedings Article | 13 February 2009 Paper

Direct Raman imaging spectroscopy of lung cancer cells and apoptotic cells

Yusuke Oshima, Chie Furihata, Hidetoshi Sato

Proceedings Volume 7182, 71820F (2009) https://doi.org/10.1117/12.808785

KEYWORDS: Raman spectroscopy, Lung cancer, Cancer, Tissues, Principal component analysis, Imaging spectroscopy, Imaging systems, Spectroscopy, Molecules, Diagnostics

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Proceedings Article | 18 March 2008 Paper

Development of a direct Raman imaging system for rapid diagnosis of malignant tumor

Yusuke Oshima, Chie Furihata, Hidetoshi Sato

Proceedings Volume 6859, 685905 (2008) https://doi.org/10.1117/12.762687

KEYWORDS: Raman spectroscopy, Imaging systems, Tissues, Image processing, CCD image sensors, Sensors, Optical filters, Visualization, Bandpass filters, Tumors

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Proceedings Article | 22 February 2006 Paper

Development of the optical biopsy system for small experimental animals

Hidetoshi Sato, Yusuke Hattori, Yusuke Oshima, Yuichi Komachi, Takashi Katagiri, Toru Asakura, Toru Shimosegawa, Yuji Matsuura, Mitsunobu Miyagi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Hideo Tashiro

Proceedings Volume 6091, 60910H (2006) https://doi.org/10.1117/12.645842

KEYWORDS: Raman spectroscopy, Stomach, Endoscopes, Blood vessels, Tissues, Cancer, Biopsy, Liquids, Head, Prototyping

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Showing 5 of 25 publications

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