Mr. Menghao Xu Profile

Menghao Xu

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Proceedings Article | 28 July 2023 Paper

The numerical model for sarcoplasmic reticulum Ca2+ blink in rabbit cardiomyocytes

Yongshen Liang, Menghao Xu

Proceedings Volume 12756, 127562Q (2023) https://doi.org/10.1117/12.2685897

KEYWORDS: Calcium, Diffusion, Fluorescence, Numerical analysis, Modeling

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Ca²⁺ in cardiac myocyte are mainly stored in the sarcoplasmic reticulum (SR), the disturbance of Ca²⁺ dynamics in the SR can cause various cardiovascular diseases. However, there is a lack of research on regulatory mechanism of SR Ca²⁺ . In this paper, we developed a spatially-detailed numerical model for Ca²⁺ blink to analyze Ca²⁺ spatiotemporal dynamic characteristics in junctional SR (jSR) cisternae of rabbit cardiomyocytes. The geometric model is constructed by 2- dimensional unstructured triangular meshes with a combined method of Delaunay Triangulations (DT) and Advancing Front Technique (AFT). The numerical method for solving the governing equations adopts Basic Function Method based on unstructured triangular meshes. Finally, our model is well reproduced the SR Ca²⁺ kinetics of Ca²⁺ blink and simulated results well match the results of a recent biological experiment.

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