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28 July 2023 The numerical model for sarcoplasmic reticulum Ca2+ blink in rabbit cardiomyocytes
Yongshen Liang, Menghao Xu
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Proceedings Volume 12756, 3rd International Conference on Applied Mathematics, Modelling, and Intelligent Computing (CAMMIC 2023); 127562Q (2023) https://doi.org/10.1117/12.2685897
Event: 2023 3rd International Conference on Applied Mathematics, Modelling and Intelligent Computing (CAMMIC 2023), 2023, Tangshan, China
Abstract
Ca2+ in cardiac myocyte are mainly stored in the sarcoplasmic reticulum (SR), the disturbance of Ca2+ dynamics in the SR can cause various cardiovascular diseases. However, there is a lack of research on regulatory mechanism of SR Ca2+ . In this paper, we developed a spatially-detailed numerical model for Ca2+ blink to analyze Ca2+ spatiotemporal dynamic characteristics in junctional SR (jSR) cisternae of rabbit cardiomyocytes. The geometric model is constructed by 2- dimensional unstructured triangular meshes with a combined method of Delaunay Triangulations (DT) and Advancing Front Technique (AFT). The numerical method for solving the governing equations adopts Basic Function Method based on unstructured triangular meshes. Finally, our model is well reproduced the SR Ca2+ kinetics of Ca2+ blink and simulated results well match the results of a recent biological experiment.
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Yongshen Liang and Menghao Xu "The numerical model for sarcoplasmic reticulum Ca2+ blink in rabbit cardiomyocytes", Proc. SPIE 12756, 3rd International Conference on Applied Mathematics, Modelling, and Intelligent Computing (CAMMIC 2023), 127562Q (28 July 2023); https://doi.org/10.1117/12.2685897
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KEYWORDS
Calcium
Diffusion
Fluorescence
Numerical analysis
Modeling
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