Retina prosthesis are implantable devices stimulating diseased retina of individuals to restore vision. New technologies are needed for precise and non-genetic retinal stimulation. Here we report the development of different photoacoustic platforms for retina stimulation. First, we demonstrated that a tapered fiber based photoacoustic emitter consistently evokes action potentials with response patterns that are sensitive to the stimulus waveform using patch clamp recordings in a retinal explant. Second, toward the implantable retinal prothesis, we confirmed successful blind retina stimulation through a PDMS-based photoacoustic film safely. These results show the potential of using optoacoustic signal to drive activity in photoreceptor-damaged retinas.
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