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13 March 2024 Photoacoustic retina stimulation
Chen Yang, Yueming Li, Linli Shi, Nan Zheng, Jae Ik Lee, Shelley Fried, Audrey Leong, Serge Picaud, Ji-Xin Cheng, Jean-Damien Lousie
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Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 1282909 (2024) https://doi.org/10.1117/12.3002078
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Retina prosthesis are implantable devices stimulating diseased retina of individuals to restore vision. New technologies are needed for precise and non-genetic retinal stimulation. Here we report the development of different photoacoustic platforms for retina stimulation. First, we demonstrated that a tapered fiber based photoacoustic emitter consistently evokes action potentials with response patterns that are sensitive to the stimulus waveform using patch clamp recordings in a retinal explant. Second, toward the implantable retinal prothesis, we confirmed successful blind retina stimulation through a PDMS-based photoacoustic film safely. These results show the potential of using optoacoustic signal to drive activity in photoreceptor-damaged retinas.
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Chen Yang, Yueming Li, Linli Shi, Nan Zheng, Jae Ik Lee, Shelley Fried, Audrey Leong, Serge Picaud, Ji-Xin Cheng, and Jean-Damien Lousie "Photoacoustic retina stimulation", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 1282909 (13 March 2024); https://doi.org/10.1117/12.3002078
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KEYWORDS
Retina
Photoacoustic spectroscopy
Action potentials
Explants
Optoacoustics
Retinal diseases
Tissues
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