Dr. Gabrio Roncucci Profile

Dr. Gabrio Roncucci

at Molteni Therapeutics SRL

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Proceedings Article | 31 January 1996 Paper

Targeted photolysis of melanoma cells by Alfa-Terthienyl derivative labeled antimelanoma monoclonal antibody

Gabrio Roncucci, A. Di Stefano, P. Soldani, P. Neri, D. Neri

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230949

KEYWORDS: Monoclonal antibodies, Melanoma, Photolysis, Proteins, Photodynamic therapy, Therapeutic agents, Molecules, Signal detection, Tumors, Photosensitizer targeting

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Antibody targeted chemotherapy is a relatively new technique which involves the specifically carrier mediated delivery ofchemotherapeutic agents to tumors or other pathogens for the treatment of such deseases. Conjugation of antibodies with photosensitizers (PSs) can also lead to potential therapeutic agents which combine photodynaniic cytotoxicity with specific antibody binding. The antibody mediated delivery of a photosensitizer molecule and the target destruction upon irradiation by light followed by production of singlet oxigen or other radicals, results in a higher therapeutic ratio compared to the conventional photodynarnic therapy (PDT). In this study the naturally occurring PS Alphà-Terthienile (ATT) was chemically derivatized with an amino group specific reactive side arm and in order to exploit its toxicity as an effector function suitable for targeted photolysis, covalently conjugated to the 225.28S monoclonal antibody (inAb) specific for the high molecular weight melanoma associated antigen (HMW-MAA). The 225-28S-ATT conjugate prepared was then tested against the melanoma cell line Co1o38 in comparison with HT29 tumor cells, not recognized by 225-28S mAb, as negative control. The selective uptake of labelled niAb 22528S-ATF and the melanoma cells death following irradiation can be observed. In conclusion the 225-28S-ATT conjugate, as far as one can judge from the effect on cells grown in vitro, seems a good candidate as a model to test the antibody targeted photolysis of melanoma cells for developing specific antimelanoma therapeutic agents.

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