This study aimed to introduce a novel approach named Vector Operation Moving Block Standard Deviation
(VO-MBSD) to characterize the original powder blend uniformity of Angong Nuihuang intermediate using NIR
technology, including 400g Rhizoma Coptidis, 400g Radix Scutellariae, 400g Radix Curcumae and 400g Fructus
Gardeniae. A novel blending evaluation method named VO-MBSD compared with Moving Block Standard Deviation
(MBSD) was applied to characterize the blending of Chinese Materia Medica (CMM) original powder including
Rhizoma Coptidis, Radix Scutellariae, Radix Curcumae and Fructus Gardeniae. HPLC (High Performance Liquid
Chromatography) analysis demonstrated these observations perfectly. OV-MBSD is the rate of change by time, which
not only represents the scalar change but also the vector change. The identification accuracy of blend uniformity and
end-point via VO-MBSD was the same with classical HPLC method. This method is more accuracy than original MBSD
method. Compared with classical MBSD, it is appropriate for the determination of blending end-point and could be
successfully implemented as an on-line monitoring tool for blending process.
Objective: A rapid and nondestructive method was used to quantitatively predict the content of three main active components (glycyrrhizin, liquiritin and isoliquiritin) in licorice by near infrared spectroscopy (NIRS). Methods: Diffuse reflectance spectra of licorice powder were obtained, the contents of glycyrrhizin, liquiritin and isoliquiritin were analyzed simultaneously by high-performance liquid chromatography (HPLC). The partial least squares (PLS) regression algorithm was used to establish the quantitative models. Several pretreatments such as multiplicative scatter correction (MSC), first derivative, second derivative and Savitzky-Golay (SG) smoothing were utilized to correct the scattering effect and eliminate the baseline shift in all spectra. The calibration equations produced the highest determination of coefficient values (R2), the lowest root mean square error of calibration (RMSEC) and the lowest root mean square error of prediction (RMSEP) were used for the determination of glycyrrhizin, liquiritin and isoliquiritin. Results: The R2 of glycyrrhizin, liquiritin and isoliquiritin were 0.999, 0.996 and 0.999, respectively. The RMSEC of glycyrrhizin, liquiritin and isoliquiritin were 1.14 mg/g, 0.77 mg/g and 0.068 mg/g respectively. The RMSEP of glycyrrhizin, liquiritin and isoliquiritin were 4.92 mg/g, 2.06 mg/g and 0.35 mg/g respectively. Conclusions: The results indicated that the NIRS method could be used for the rapid assessment of licorice.
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