Dr. Ying Yang Profile

Dr. Ying Yang

Senior Lecturer/Biomaterials & Tissue Engineering at Keele Univ

SPIE Involvement:

Author

Publications (37)

Proceedings Article | 16 March 2023 Presentation

Characterisation and quantification of the limbal architecture and biomechanical properties using optical coherence tomography or elastography (Conference Presentation)

Ryan Dimmock, Yilong Zhang, Gibran Butt, Zhihong Huang, Saeeha Rauz, Ying Yang

Proceedings Volume PC12393, PC1239304 (2023) https://doi.org/10.1117/12.2650277

KEYWORDS: Optical coherence tomography, Elastography, Tissue optics, Tissues, Stem cells, Statistical analysis, Cornea, Coherence (optics)

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Proceedings Article | 21 February 2019 Paper

Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography

Jonathan Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre Bagnaninchi

Proceedings Volume 10880, 108801K (2019) https://doi.org/10.1117/12.2508326

KEYWORDS: Denoising, Elastography, Motion estimation, Coherence (optics), Optical coherence tomography, Image enhancement, Statistical analysis, Image quality, Image resolution, Image analysis

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Proceedings Article | 21 February 2019 Presentation + Paper

Real-time and non-invasive quantitative phase imaging of pancreatic ductal adenocarcinoma cell mechanical properties

D. Gillies, W. Gamal, M. Canel, Y. Reinwald, Y. Yang, A. J. El Haj, A. Serrels, P. Bagnaninchi

Proceedings Volume 10880, 108800H (2019) https://doi.org/10.1117/12.2508436

KEYWORDS: Digital holography, Phase imaging, Microscopy, Cancer, Cell mechanics, Stem cells, Elastography

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Proceedings Article | 21 February 2019 Paper

Model-based iterative reconstruction for spectral-domain optical coherence tomography

Jonathan Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre Bagnaninchi

Proceedings Volume 10883, 108830O (2019) https://doi.org/10.1117/12.2509424

KEYWORDS: Optical coherence tomography, Model-based design, Reconstruction algorithms, Systems modeling, Spectroscopy, Fourier transforms, Tissues, Visualization, Medicine, Statistical modeling

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Proceedings Article | 21 February 2019 Paper

Evaluation of human corneal ulcer healing process using optical coherence tomography: an in vitro study

Yuting Ling, Chunhui Li, Christine Purslow, Ying Yang, Zhihong Huang

Proceedings Volume 10880, 108801H (2019) https://doi.org/10.1117/12.2509486

KEYWORDS: Tissues, Wound healing, 3D modeling, Optical coherence tomography, Cornea, In vitro testing, Collagen, Injuries, Animal model studies, Eye models

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Proceedings Article | 21 February 2017 Presentation + Paper

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy

D. Gillies, W. Gamal, A. Downes, Y. Reinwald, Y. Yang, A. El Haj, P. Bagnaninchi

Proceedings Volume 10067, 100670Y (2017) https://doi.org/10.1117/12.2251492

KEYWORDS: Tissue optics, Coherence (optics), Optical microscopy, Microscopy, Microfluidics, Phase measurement, Elastography, Tissue engineering, Environmental monitoring, Stem cells, Data modeling, Optical coherence tomography, Water

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Proceedings Article | 17 March 2016 Paper

OCT as a convenient tool to assess the quality and application of organotypic retinal samples

Rachel Gater, Nicholas Khoshnaw, Dan Nguyen, Alicia El Haj, Ying Yang

Proceedings Volume 9707, 97071C (2016) https://doi.org/10.1117/12.2213509

KEYWORDS: Tissues, Optical coherence tomography, Retina, Imaging spectroscopy, Tissue engineering, Regenerative medicine, Therapeutics, Tissue optics, Refraction, Vitreous, Collagen, Eye, Animal model studies, In vitro testing, Eye models

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Proceedings Article | 9 March 2016 Paper

Online monitoring of mechanical properties of three-dimensional tissue engineered constructs for quality assessment

Yvonne Reinwald, Pierre Bagnaninchi, Ying Yang, Yanny Baba Ismail, Alicia El Haj

Proceedings Volume 9710, 971007 (2016) https://doi.org/10.1117/12.2212320

KEYWORDS: Elastography, Tissues, Tissue optics, Coherence (optics), 3D image processing, Tissue engineering, In vivo imaging, Manufacturing, Optical coherence tomography, Interfaces, Solids, Prototyping

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Proceedings Article | 5 March 2015 Paper

Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs

Guangying Guan, Shaozhen Song, Zhihong Huang, Ying Yang

Proceedings Volume 9322, 93220G (2015) https://doi.org/10.1117/12.2078013

KEYWORDS: Bone, Particles, Elastography, Tissues, Tissue engineering, Tissue optics, Coherence (optics), In vitro testing, Modulation, Acoustics

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SPIE Journal Paper | 5 September 2014 Open Access

Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy

Marie Guilbert, Christophe Eklouh-Molinier, Katia Wehbe, Josep Sulé-Suso, Ying Yang, Gianfelice Cinque, Pierre Jeannesson, Ganesh Sockalingum

JBO, Vol. 19, Issue 11, 111612, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.111612

KEYWORDS: Collagen, Tumors, Imaging spectroscopy, FT-IR spectroscopy, Proteins, Cancer, Synchrotrons, Infrared radiation, Infrared imaging, Biological research

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Proceedings Article | 26 February 2014 Paper

Label free cell tracking in 3D tissue engineering constructs with high resolution imaging

W. Smith, K.-P. Lam, K. Dempsey, D. Mazzocchi-Jones, J. Richardson, Y. Yang

Proceedings Volume 8942, 894209 (2014) https://doi.org/10.1117/12.2039354

KEYWORDS: Nanofibers, 3D image processing, Phase contrast, Tissue engineering, Algorithm development, Microscopy, Neurons, Objectives, Image resolution, Microscopes

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SPIE Journal Paper | 5 November 2013 Open Access

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Jan Vorstius, Robert Keatch, Ruikang Wang, Zhihong Huang

JBO, Vol. 18, Issue 11, 111417, (November 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111417

KEYWORDS: Elastography, Optical coherence tomography, Acoustics, Tissues, Magnesium, Biomedical optics, Coherence (optics), Signal detection, Collagen, Ultrasonography

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Proceedings Article | 1 March 2013 Paper

Optical coherence tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface

Amy Judd, Gary Moss, Jon Heylings, Ka-Wai Wan, Ying Yang

Proceedings Volume 8580, 85800G (2013) https://doi.org/10.1117/12.2004754

KEYWORDS: Skin, Dendrimers, Optical coherence tomography, Diffusion, Tissues, Refractive index, Natural surfaces, Reflectivity, Scattering, Interfaces

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SPIE Journal Paper | 18 January 2013 Open Access

Errata: Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

Ying Yang, Asha Rupani, Pierre Bagnaninchi, Ian Wimpenny, Alan Weightman

JBO, Vol. 18, Issue 01, 019801, (January 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.1.019801

KEYWORDS: Optical properties, Polarization, Optical coherence tomography, Biomedical optics, Medicine, Regenerative medicine

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SPIE Journal Paper | 2 August 2012 Open Access

Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

Ying Yang, Asha Rupani, Ian Wimpenny, Alan Weightman, Pierre Bagnaninchi

JBO, Vol. 17, Issue 8, 081417, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081417

KEYWORDS: Collagen, Polarization, Birefringence, Optical fibers, Microscopy, Optical properties, Optical coherence tomography, Molecules, Visualization, Tissues

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Proceedings Article | 9 February 2012 Paper

The effect of collagen ageing on its structure and cellular behaviour

Samantha Wilson, Marie Guilbert, Josep Sulé-Suso, James Torbet, Pierre Jeannesson, Ganesh Sockalingum, Ying Yang

Proceedings Volume 8222, 822210 (2012) https://doi.org/10.1117/12.908749

KEYWORDS: Collagen, Tissues, Magnetism, Optical coherence tomography, Proteins, Molecules, Nondestructive evaluation, In vitro testing, Fluorescence correlation spectroscopy, Nitrogen

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Proceedings Article | 8 February 2011 Paper

The study of optical properties and proteoglycan content of tendons by PS-OCT

Ying Yang, Asha Rupani, Alan Weightman, Ian Wimpenny, Pierre Bagnaninchi, Mark Ahearne

Proceedings Volume 7898, 789808 (2011) https://doi.org/10.1117/12.877113

KEYWORDS: Collagen, Polarization, Birefringence, Optical fibers, Microscopy, Tissues, Optical properties, Optical coherence tomography, Microscopes, Molecules

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Tendons are load-bearing collagenous tissues consisting mainly of type I collagen and various proteoglycans (PGs) including decorin and versican. It is widely accepted that highly orientated collagen fibers in tendons a play critical role for transferring tensile stress and demonstrate birefringent optical properties. However, the influence that proteoglycans have on the optical properties of tendons is yet to be fully elucidated. Tendinopathy (defined as a syndrome of tendon pain, tenderness and swelling that affects the normal function of the tissue) is a common disease associated with sporting injuries or degeneration. PG's are the essential components of the tendon extracellular matrix; changes in their quantities and compositions have been associated with tendinopathy. In this study, polarization sensitive optical coherence tomography (PS-OCT) has been used to reveal the relationship between proteoglycan content/location and birefringent properties of tendons. Tendons dissected from freshly slaughtered chickens were imaged at regular intervals by PS-OCT and polarizing light microscope during the extraction of PGs or glycosaminoglycans using established protocols (guanidine hydrochloride (GuHCl) or proteinase K solution). The macroscopic and microscopic time lapsed images are complimentary; mutually demonstrating that there was a higher concentration of PG's in the outer sheath region than in the fascicles; and the integrity of the sheath affected extraction process and the OCT birefringence bands. Extraction of PGs using GuHCl disturbed the organization of local collagen bundles, which corresponded to a reduction in the frequency of birefringence bands and the band width by PS-OCT. The feature of OCT penetration depth helped us to define the heterogeneous distribution of PG's in tendon, which was complimented by polarizing light microscopy. The results provide new insight of tendon structure and also demonstrate a great potential for using PS-OCT as a diagnostic tool to examine tendon pathology.

Proceedings Article | 25 February 2010 Paper

The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT

Ying Yang, Andreea Iftimia, Yali Jia, Toby Gould, Alicia El Haj, Ruikang Wang

Proceedings Volume 7566, 75660J (2010) https://doi.org/10.1117/12.842266

KEYWORDS: Optical coherence tomography, Optical spheres, Tissue engineering, Doppler tomography, Fluid dynamics, Tissues, Manufacturing, Nondestructive evaluation, Polymers, Fabrication

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Proceedings Article | 25 February 2010 Paper

Investigation of a tissue engineered tendon model by PS-OCT

Ying Yang, Mark Ahearne, Ian Wimpenny, Juan Guijarro-Leach, Jim Torbet

Proceedings Volume 7566, 75660A (2010) https://doi.org/10.1117/12.842302

KEYWORDS: Collagen, Nanofibers, Birefringence, Tissues, Magnetism, Image compression, Tissue engineering, Optical fibers, Microscopes, Optical coherence tomography

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SPIE Journal Paper | 1 May 2009 Open Access

Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds

Yali Jia, Pierre-Olivier Bagnaninchi, Ying Yang, Alicia El Haj, Monica Hinds, Sean Kirkpatrick, Ruikang Wang

JBO, Vol. 14, Issue 03, 034014, (May 2009) https://doi.org/10.1117/12.10.1117/1.3130345

KEYWORDS: Optical coherence tomography, Microfluidics, Microfluidic imaging, Coherence imaging, Doppler tomography, Tissues, 3D image processing, Optical imaging, Tissue engineering, 3D modeling

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Proceedings Article | 24 February 2009 Paper

Elastin peptides increase lung cancer cell growth in 3D models

Jacek Pijanka, Ying Yang, Pierre Bagnaninchi, Laurent Debelle, Ganesh Sockalingum, Josep Sulé-Suso

Proceedings Volume 7179, 717907 (2009) https://doi.org/10.1117/12.813743

KEYWORDS: 3D modeling, Lung cancer, Cancer, Tumor growth modeling, Collagen, Optical coherence tomography, Lung, Tissues, Systems modeling, Biomedical optics

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Proceedings Article | 19 February 2009 Paper

Assessment of a new biomimetic scaffold and its effects on bone formation by OCT

Ying Yang, Halil Aydin, Erhan Piskin, Alicia El Haj

Proceedings Volume 7166, 71660L (2009) https://doi.org/10.1117/12.809208

KEYWORDS: Bone, Optical coherence tomography, Collagen, Particles, Polymers, Tissue engineering, Minerals, Biomimetics, Scanning electron microscopy, Birefringence

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Proceedings Article | 12 February 2009 Paper

Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by PSOCT

Ying Yang, Mark Ahearne, Ian Wimpenny, Jim Torbet

Proceedings Volume 7179, 717903 (2009) https://doi.org/10.1117/12.809231

KEYWORDS: Collagen, Tissues, Birefringence, Tissue engineering, Magnetism, Polarization, Microscopy, Optical coherence tomography, Optical fibers, In vitro testing

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Proceedings Article | 29 February 2008 Paper

Study of melanoma invasion by FTIR spectroscopy

Y. Yang, J. Sulé-Suso, G. Sockalingum

Proceedings Volume 6859, 68591U (2008) https://doi.org/10.1117/12.763770

KEYWORDS: FT-IR spectroscopy, Skin, Melanoma, Proteins, Spectroscopy, 3D modeling, Associative arrays, Tissues, Process control, Infrared radiation

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Proceedings Article | 20 February 2008 Paper

Optical properties of human tendons characterized by PSOCT and their relation to tendinopathy: a clinical study

P. Bagnaninchi, D. Churmakov, M. Bonesi, Y. Yang, C. Phelan, N. Maffulli, I. Meglinski, A. El Haj

Proceedings Volume 6854, 68541C (2008) https://doi.org/10.1117/12.763156

KEYWORDS: Polarization, Scattering, Birefringence, Tissues, Optical coherence tomography, Optical properties, Beam splitters, Tissue optics, Polarizers, Sensors

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Proceedings Article | 11 February 2008 Paper

Application of polarization OCT in tissue engineering

Ying Yang, Mark Ahearne, Pierre Bagnaninchi, Bin Hu, Karen Hampson, Alicia El Haj

Proceedings Volume 6858, 68580K (2008) https://doi.org/10.1117/12.762958

KEYWORDS: Tissues, Optical coherence tomography, Collagen, Tissue engineering, Birefringence, Polarization, Nondestructive evaluation, Tissue optics, Superluminescent diodes, Microscopes

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Proceedings Article | 8 February 2007 Paper

Characterization of scaffold architecture by optical coherence tomography

Ying Yang, Pierre Bagnaninchi, Cassilda Cunha-Reis, Halil Aydin, Erhan Piskin, Alicia El Haj

Proceedings Volume 6439, 64390G (2007) https://doi.org/10.1117/12.701103

KEYWORDS: Optical coherence tomography, Tissues, Polymers, Tissue engineering, Manufacturing, Fabrication, Confocal microscopy, Crystals, Microscopy, Nondestructive evaluation

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Proceedings Article | 8 February 2007 Paper

Characterization of local fluid flow in 3D porous construct characterized by Fourier domain Doppler optical coherence tomography

P. Bagnaninchi, Y. Yang, A. El Haj, M. Hinds, R. Wang

Proceedings Volume 6439, 64390H (2007) https://doi.org/10.1117/12.701083

KEYWORDS: Microfluidics, Tissues, Optical coherence tomography, Tissue engineering, Doppler tomography, Microfluidic imaging, Tissue optics, Fluid dynamics, Scattering, 3D image processing

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Proceedings Article | 7 February 2007 Paper

Continuous monitoring of tissue growth inside a perfusion bioreactor by optical coherence tomography

P. Bagnaninchi, A. El Haj, Y. Yang

Proceedings Volume 6439, 643903 (2007) https://doi.org/10.1117/12.701052

KEYWORDS: Tissues, Optical coherence tomography, Tissue engineering, Scattering, Tissue optics, In vitro testing, Microfluidics, Superluminescent diodes, Nondestructive evaluation, Collagen

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Proceedings Article | 7 February 2007 Paper

A novel OCT-based micro-indentation technique for mechanical characterization of soft tissues

Ying Yang, Pierre Bagnaninchi, Mark Ahearne, Ruikang Wang, Kuo-Kang Liu

Proceedings Volume 6439, 643907 (2007) https://doi.org/10.1117/12.700819

KEYWORDS: Tissues, Optical coherence tomography, Nondestructive evaluation, Spherical lenses, Image resolution, Coherence imaging, Solids, Optical resolution, Optical imaging, Light sources

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Proceedings Article | 1 March 2006 Paper

Monitoring tissue formation and organization of engineered tendon by optical coherence tomography

P. Bagnaninchi, Y. Yang, N. Maffulli, R. Wang, A. El Haj

Proceedings Volume 6084, 608419 (2006) https://doi.org/10.1117/12.646186

KEYWORDS: Optical coherence tomography, Tissues, Tissue engineering, Collagen, Confocal microscopy, Tissue optics, Traumatic brain injury, Nondestructive evaluation, Optical engineering, Structured optical fibers

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Proceedings Article | 28 February 2006 Paper

Study cell invasion by optical techniques

Ying Yang, Paul Hoban, Joseph Sule-Suso, Sarah Holley, Alicia El Haj, Fariba Bahrami, Ruikang Wang

Proceedings Volume 6084, 60841A (2006) https://doi.org/10.1117/12.646330

KEYWORDS: FT-IR spectroscopy, Collagen, Optical coherence tomography, Cancer, Microscopy, Tissue optics, Tumors, Control systems, Proteins, Microscopes

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Proceedings Article | 15 April 2005 Paper

Monitoring cell profile in tissue engineered constructs by OCT

Ying Yang, Pierre Bagnaninchi, Mairead Wood, Alicia El Haj, Elvire Guyot, Arnaud Dubois, Ruikang Wang

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.592752

KEYWORDS: Optical coherence tomography, Tissues, Tissue engineering, Tissue optics, Bone, Polymers, Nondestructive evaluation, Proteins, Biological research, Magnetic resonance imaging

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Proceedings Article | 13 April 2005 Paper

Application of optical coherence tomography for tissue engineering

Ying Yang, Ruikang Wang, Elvire Guyot, Alicia El Haj, Arnaud Dubois

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592691

KEYWORDS: Optical coherence tomography, Tissue engineering, Tissues, Bone, Tissue optics, Polymers, Magnetism, Nondestructive evaluation, Michelson interferometers, Imaging systems

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Proceedings Article | 13 April 2005 Paper

Ultrahigh-resolution optical imaging of cellular structures of high-scattering biological tissues with whole-field optical coherence microcopy

Ruikang Wang, Ying Yang, Elvire Guyot, Arnaud Dubois

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592671

KEYWORDS: Optical coherence tomography, Tissues, Imaging systems, Image resolution, Scattering, Optical imaging, Cartilage, Biomedical optics, Coherence (optics), Tissue optics

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Proceedings Article | 29 July 2004 Paper

Optical coherence tomography imaging of structural components of the respiratory tract

Suzanne Whiteman, Ying Yang, D. Gey van Pittius, Yonghong He, M. Spiteri, Ruikang Wang

Proceedings Volume 5486, (2004) https://doi.org/10.1117/12.572000

KEYWORDS: Optical coherence tomography, Tissues, Cartilage, Tissue optics, Coherence imaging, Spatial resolution, Diagnostics, Imaging systems, Image resolution, Lung

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Proceedings Article | 29 July 2004 Paper

Use of OCT to study tumor cell growth in 3D membranes

Ying Yang, Josep Sule-Suso, Alicia El Haj, Paul Hoban, Ruikang Wang

Proceedings Volume 5486, (2004) https://doi.org/10.1117/12.571998

KEYWORDS: Optical coherence tomography, Collagen, Mesothelioma, Coherence imaging, Lung, Tissues, Tissue optics, Imaging systems, Refractive index, Tumors

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