HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λex: 780 nm, λem: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.
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