Mr. Scott Selfridge Profile

Scott Selfridge

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 9 March 2022 Presentation + Paper

EGFR-targeted multi-modal molecular imaging and treatment in a heterocellular model of head and neck cancer

Mohammad Saad, Leslie Contreras, Shazia Bano, Scott Selfridge, Zhiming Mai, Robert Pawle, Mark Varvares, Srivalleesha Mallidi, Tayyaba Hasan

Proceedings Volume 11935, 1193507 (2022) https://doi.org/10.1117/12.2610047

KEYWORDS: Tumors, Luminescence, Cancer, Neck, Head, Surgery, Tissues, Tissue optics, Photoacoustic spectroscopy, Photoimmunotherapy, Photodynamic therapy, Molecular imaging

Read Abstract +

Precision molecular imaging finds application in the delineation of tumor margins during surgical resection of head and neck cancers (HNCs). Despite the advantages of surgery, there remain challenges in successfully locating tumor margins, resecting the entire tumor volume and treatment of microscopic tumor tissue. The presence of residual tumors, post-surgery, may require additional interventions and often lead to tumor recurrence. While Epidermal growth factor receptor (EGFR) remains a receptor of choice for targeting in HNCs, the heterogeneity in the expression of EGFR often leads to variations in response to targeted therapeutics. To improve visualization and tumor margin delineation during head and neck tumor surgeries, this study demonstrates the development of a molecular targeted theranostic probe combining the complementary features of fluorescence and photoacoustic imaging. The probe: DFAC (Dual Function Antibody Conjugate) comprises of a fluorophore/photosensitizer; Benzoporphyrin derivative (BPD) and a photoacoustic contrast agent; naphthalocyanine (NC) derivative conjugated to an EGFR antibody; Cetuximab. While BPD assists in fluorescence imaging, it can also be used for inducing cytotoxicity, through photodynamic activation in target tissues. The efficacy of DFAC in selective visualization and photodynamic therapy of tumor cells is evaluated on heterocellular 3D tumor spheroids and orthotopic mouse tongue tumors developed from human oral cancer cell lines (CAL27 and SCC4), expressing different levels of EGFR. In summary, this study demonstrates the potential of the theranostic probe (DFAC) to delineate tumor regions for guiding surgical resection and eradicate residual tumor tissue (post-surgery) by photodynamic therapy.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years