Ms. Liping Cui Profile

Liping Cui

at Institute of Optics Univ of Rochester

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SPIE Journal Paper | 1 March 2010 Open Access

Forty-five degree backscattering-mode nonlinear absorption imaging in turbid media

Liping Cui, Wayne Knox

JBO, Vol. 15, Issue 02, 026004, (March 2010) https://doi.org/10.1117/12.10.1117/1.3368995

KEYWORDS: Monte Carlo methods, Absorption, Nonlinear optics, Signal detection, Backscatter, Capillaries, Sensors, Imaging systems, Calibration, Scattering

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Two-color nonlinear absorption imaging has been previously demonstrated with endogenous contrast of hemoglobin and melanin in turbid media using transmission-mode detection and a dual-laser technology approach. For clinical applications, it would be generally preferable to use backscattering mode detection and a simpler single-laser technology. We demonstrate that imaging in backscattering mode in turbid media using nonlinear absorption can be obtained with as little as 1-mW average power per beam with a single laser source. Images have been achieved with a detector receiving backscattered light at a 45-deg angle relative to the incoming beams' direction. We obtain images of capillary tube phantoms with resolution as high as 20 µm and penetration depth up to 0.9 mm for a 300-µm tube at SNR ~1 in calibrated scattering solutions. Simulation results of the backscattering and detection process using nonimaging optics are demonstrated. A Monte Carlo-based method shows that the nonlinear signal drops exponentially as the depth increases, which agrees well with our experimental results. Simulation also shows that with our current detection method, only 2% of the signal is typically collected with a 5-mm-radius detector.

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