Mr. Kumar Ashutosh Profile

Kumar Ashutosh

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 23 October 2018 Paper

Comparative study between diagnostic mediums: human tissue and saliva for oral cancer detection using Stokes shift spectroscopy

Pavan Kumar, Kumar Ashutosh, Asima Pradhan

Proceedings Volume 10820, 108200L (2018) https://doi.org/10.1117/12.2501173

KEYWORDS: Tissues, Cancer, Spectroscopy, Diagnostics, Fluorescence spectroscopy, Tissue optics, Collagen, Principal component analysis, Raman spectroscopy, Blood

Read Abstract +

A comparative study has been accomplished between diagnostic mediums: human oral tissue and saliva for oral cancer detection on three groups: oral squamous cell carcinoma (OSCC), dysplastic, and control (normal) by using Stokes shift (SS) spectroscopy (SSS) at ▵λ of 120 nm, which is the Stokes shift of nicotinamide adenine dinucleotide (NADH). SS spectra obtained from tissue and saliva consist of major bands of collagen, tryptophan, NADH and minor bands of flavin adenine dinucleotide (FAD) and porphyrin. Principal component analysis (PCA) has been performed on the data sets of SS spectra for discrimination by dimension reduction. Linear discriminant analysis (LDA) has been applied on the PC scores to compute linear discriminant (LD) scores. Kernel probability density functions of LD scores are plotted to show how LD scores of each group are separated from one another. LD scores for oral tissue differentiates OSCC to normal, dysplasia to normal, and OSCC to dysplasia with sensitivities 100 %, 85 %, 94 % and specificities 88 %, 88 %, 89 % with the accuracy of 95 %, 87 % and 92 %. On the other hand for saliva, it differentiates respective groups with sensitivities 91 %, 82 %, 91 % and specificities 100 %, 88 %, 82 % with the accuracy of 95 %, 85 % and 87 %. Obtained results with human saliva are as prominent as oral tissue and we conclude that it may be used as a substitute diagnostic medium. In addition SS spectroscopy instead of fluorescence spectroscopy at 120 nm shift appears to be an important tool for in vivo detection of early oral cancer.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years