Psoralen plus ultraviolet A radiation (PUVA) therapy is a very important clinical treatment of skin diseases such as
vitiligo and psoriasis, but associated with an increased risk of skin photodamages especially photoaging. Since skin
biopsy alters the original skin morphology and always requires an iatrogenic trauma, optical coherence tomography
(OCT) appears to be a promising technique to study skin damage in vivo. In this study, the Balb/c mice had
8-methoxypsralen (8-MOP) treatment prior to UVA radiation was used as PUVA-induced photo-damaged modal. The
OCT imaging of photo-damaged group (modal) and normal group (control) in vivo was obtained of mice dorsal skin at 0,
24, 48, 72 hours after irradiation respectively. And then the results were quantitatively analyzed combined with
histological information. The experimental results showed that, PUVA-induced photo-damaged skin had an increase in
epidermal thickness (ET), a reduction of attenuation coefficient in OCT images signal, and an increase in brightness of
the epidermis layer compared with the control group. In conclusion, noninvasive high-resolution imaging techniques
such as OCT may be a promising tool for photobiological studies aimed at assessing photo-damage and repair processes
in vivo. It can be used to quantitative analysis of changes in photo-damaged skin, such as the ET and collagen in dermis,
provides a theoretical basis for treatment and prevention of skin photodamages.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.