KEYWORDS: Photoacoustic spectroscopy, Near infrared, Semiconductors, Pulsed laser operation, Polymers, New and emerging technologies, Neurons, Nanoparticles, Modulation, In vivo imaging
Toward non-genetic non-invasive neural modulation with a submillimeter precision, we report the development and application of photoacoustic nanotransducers (PAN) to neural stimulation in cultured primary neurons and in live brain. Our PAN, based on synthesized semiconducting polymer nanoparticles, efficiently generate localized ultrasound by a photoacoustic process upon absorption of nanosecond pulsed light in the NIR-II window. We showed that PAN binding on the neuron membrane through non-specific interaction and specific targeting of mechanosensitive ion channels both successfully activate primary neurons in culture. We also demonstrated in live mouse brain motor cortex activation and invoked subsequent motor responses through PAN.
Plastics are arguably the most ubiquitous structural materials mankind invented, while semiconducting polymers, one kind of special plastics, present their unique optical and electronic characteristics and have attracted wide interest from biomedical to electronic applications. In this talk, we focus on our latest development of semiconducting polymer blends for organic electronics. We will discuss how we came up with the concept of complementary semiconducting polymer blends that render melt-processability to the solvent-free fabrication of thin film organic electronics, a clear departure from widely practiced solution processing which often involves toxic and environmentally-harmful organic solvents. We will also highlight the marriage of semiconducting polymers and insulating plastics that brings stable charge transport across a wide temperature range from room temperature up to 220°C in thin-film transistors. This discovery lifts the limitation by the fact that most electronics will break down at high temperatures and could be a way to change that.
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