Mr. Jeetender-Singh Amritsar Gobind Profile

Jeetender-Singh Amritsar Gobind

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Publications (7)

Proceedings Article | 8 September 2006 Paper

Behaviour of enzyme molecules under piezo-electric vibrations

Amritsar Jeetender, Ion Stiharu, Muthukumaran Packirisamy, Vahé Nerguizian

Proceedings Volume 6343, 634340 (2006) https://doi.org/10.1117/12.708257

KEYWORDS: Molecules, Diagnostics, Ferroelectric polymers, Power supplies, Microelectromechanical systems, Actuators, Aluminum, Gold, Fluorescence spectroscopy, Point-of-care devices

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Proceedings Article | 21 April 2006 Paper

MEMS-based sensor and method for optical detection of peptides bio-reaction time

Amritsar Jeetender, Ion Stiharu, Muthukumaran Packirisamy, Vahé Nerguizian

Proceedings Volume 6186, 61860G (2006) https://doi.org/10.1117/12.662810

KEYWORDS: Microelectromechanical systems, Scanning electron microscopy, Sensors, Absorption, Molecules, Biosensors, Ferroelectric polymers, Diagnostics, FT-IR spectroscopy, Spectroscopy

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SPIE Journal Paper | 1 March 2006 Open Access

Bioenzymatic detection of troponin C using micro-opto-electro-mechanical systems

Amritsar Jeetender, Ion Stiharu, Packirisamy Muthukumaran

JBO, Vol. 11, Issue 02, 021010, (March 2006) https://doi.org/10.1117/12.10.1117/1.2186326

KEYWORDS: Proteins, FT-IR spectroscopy, Molecules, Fluorescence spectroscopy, Calcium, Beam shaping, Biological research, Biosensors, Ferroelectric polymers, Molecular biology

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Proceedings Article | 13 October 2005 Paper

Micro-opto mechanical biosensors for enzymatic detection

Jeetender Amritsar, Stiharu Ion, Packirisamy Muthukumaran

Proceedings Volume 5969, 59690V (2005) https://doi.org/10.1117/12.628797

KEYWORDS: Biosensors, Ferroelectric polymers, Proteins, Scanning electron microscopy, Sensors, Molecules, Laser sources, Microelectromechanical systems, Transducers, Hydrogen

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Miniaturization and highly accurate detection technologies are key factors to advancing sensor performance and utility and the search for such technologies promises accomplishments with the advent of Micro Electro Mechanical Systems (MEMS) structures. MEMS is an enabling technology that can create integrated devices with mechanical, optical and electronic components. One of the fields where these micro-devices are successfully widespread is that of medical care where micro-machined cantilever sensors are found to be the ideal candidates for bio-sensing applications. These micro-machined cantilevers have been proposed as mechanical transducers for different sensing applications. These sensing surfaces are of interest in the development of novel cantilever-based biosensors. The fascinating aspect about these transducers is that they bend due to modifications in nano-mechanical interactions between neighboring molecules which curve the beam and that curvature can be optically detected. In this paper, PVDF-cantilevers are coated with 2 sets of antibody and antigen on one side, which respond with specific deflection signatures to each other and their intermolecular nano-mechanics bend the cantilever. The first set of antibody and antigen used here are rabbit skeletal muscle Troponin C (TnC) and Honey Bee Venom Melittin (ME) prepared in 50mM KCl and 50mM Tris-HCl buffer at a pH of 7.5 in a 1:1 ratio. The next set used were Horse Raddish Peroxide (HRP) and Hydrogen Peroxide (H2O2) prepared to get 10mg per 1ml of 0.1M Potassium Phosphate dibasic (K2HPO4) and diluted hydrochloric acid to get pH of 6.0. The optical system includes a laser source and a Position Sensitive Detector (PSD) which is used to readout deflections of the PVDF-cantilevers. The behavior of the cantilevers was also monitored with the enzymes under the influence of voltage. The classical problem of evaluating the tip deflection of the cantilever beam is analyzed involving the relation between movement recorded by the PSD, the tip deflection and angle of incidence. The combined results provide valuable information on the development of an optimizing sensing element that would enable life saving treatments of patients suffering from Acute Myocardial Infarction (AMI).

Proceedings Article | 28 April 2005 Paper

Enzymatic detection of troponin C and melittin bee

Amritsar Jeetender, Ion Stiharu, Muthukumaran Packirisamy

Proceedings Volume 5705, (2005) https://doi.org/10.1117/12.592181

KEYWORDS: Calcium, Proteins, Luminescence, Biosensors, Absorbance, Absorption, Content addressable memory, FT-IR spectroscopy, Quartz, Diagnostics

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Proceedings Article | 9 December 2004 Paper

MOEMS-based cardiac enzymes detector for acute myocardial infarction

Jeetender Amritsar, Ion Stiharu, Muthukumaran Packirisamy, Ganesharam Balagopal, Xing Li

Proceedings Volume 5578, (2004) https://doi.org/10.1117/12.567678

KEYWORDS: Glasses, FT-IR spectroscopy, Sensors, Biosensors, Spectrophotometry, Absorbance, Proteins, Microopto electromechanical systems, Biomedical optics, Microelectromechanical systems

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Proceedings Article | 16 August 2004 Paper

Micro-electro-mechanical systems (MEMS) for enzymatic detection

Amritsar Jeetender, Muthukumaran Packirisamy, Ion Stiharu, Ganesharam Balagopal

Proceedings Volume 5455, (2004) https://doi.org/10.1117/12.547545

KEYWORDS: Microelectromechanical systems, Sensors, Hydrogen, Atomic force microscopy, Reflection, Temperature metrology, Lenses, Molecules, BioMEMS, Silicon

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Showing 5 of 7 publications

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