Ms. Jasmine Poirier Profile

Jasmine Poirier

at Zilia

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Publications (2)

SPIE Journal Paper | 15 December 2023 Open Access

Targeted spectroscopy in the eye fundus

Nicolas Lapointe, Cléophace Akitegetse, Jasmine Poirier, Maxime Picard, Patrick Sauvageau, Dominic Sauvageau

JBO, Vol. 28, Issue 12, 126004, (December 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.12.126004

KEYWORDS: Eye, Spectroscopy, Fluorescence, Target acquisition, Optic nerve, Light emitting diodes, Head, Eye models, Light sources and illumination, Imaging spectroscopy

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SignificanceThe assessment of biomarkers in the eye is rapidly gaining traction for the screening, diagnosis, and monitoring of ocular and neurological diseases. Targeted ocular spectroscopy is a technology that enables concurrent imaging of the eye fundus and analysis of high-quality spectra from a targeted region within the imaged area. This provides structural, compositional, and functional information of specific regions of the eye fundus from a non-invasive approach to ocular biomarker detection.AimThe aim of our study was to demonstrate the multimodal functionality and validation of targeted ocular spectroscopy. This was done in vitro, using a reference target and a model eye, and in vivo.ApproachImages and spectra from different regions of a reference target and a model eye were acquired and analyzed to validate the system. Targeted ocular fluorescence spectroscopy was also demonstrated with the same model. Subsequently, in vivo imaging and diffuse reflectance spectra were acquired to assess blood oxygen saturation in the optic nerve head and the parafovea of healthy subjects.ResultsTests conducted with the reference target showed accurate spectral analysis within specific areas of the imaging space. In the model eye, distinct spectral signatures were observed for the optic disc, blood vessels, the retina, and the macula, consistent with the variations in tissue composition and functions between these regions. An ocular oximetry algorithm was applied to in vivo spectra from the optic nerve head and parafovea of healthy patients, showing significant differences in blood oxygen saturation. Finally, targeted fluorescence spectral analysis was performed in vitro.ConclusionsDiffuse reflectance and fluorescence spectroscopy in specific regions of the eye fundus open the door to a whole new range of monitoring and diagnostic capabilities, from assessment of oxygenation in glaucoma and diabetic retinopathy to photo-oxidation and photodegradation in age-related macular degeneration.

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Proceedings Article | 17 March 2023 Poster

Targeted spectral acquisition in the eye fundus

Nicolas Lapointe, Cleophace Akitegetse, Jasmine Poirier, Maxime Picard, Dominic Sauvageau

Proceedings Volume PC12360, PC123601L (2023) https://doi.org/10.1117/12.2654669

KEYWORDS: Eye, Target acquisition, Eye models, Retina, Fluorescence spectroscopy, Diffuse reflectance spectroscopy, Tissue optics, Spectroscopy, Skin, Optical properties

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