Quantification of total hemoglobin concentrations [tHb] is imperative to determine blood-related diseases such as anemia. In this work, we validate [tHb] estimates by visible-light spectroscopic optical coherence tomography (vis-sOCT) with the gold standard, intravenous blood sample analysis from a commercial avoximeter. We recruited a group of 27 volunteers and retrieved [tHb] with vis-sOCT data from the microcirculation in the skin of the left posterior forearm. Expected [tHb] were obtained from blood sample analysis by a commercial analyzer. We compare the [tHb] estimated by vis-sOCT with the expected [tHb]. Additionally, the effect of multiple factors of influence such as gender, skin tone, and epidermal thickness is investigated.
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