Pulse oximeters overestimate the oxygen saturation in people with higher melanin concentration limiting their ability to get care or coverage. Our research has identified the sources of error to be the relationship between oxygen saturation and red-to-infrared ratio and insufficient information about the contribution of skin pigmentation to the measurements. Our design addresses these sources of errors. Due to the racial inequities in data from existing clinical trials, we will initially use precisely designed optical phantoms, followed by in vitro tests. In this talk, we will be presenting the design, the challenges, and our approach to addressing them.
Endometriosis is a chronic inflammatory disease in women aged from 20 to 40. While laparoscopy and MRI are commonly used methods for detecting endometriosis, its diagnosis remains a challenge due to variations in location of endometrial tissue and symptoms which can vary between individuals. We are designing a low-cost photoacoustic imaging system to detect endometriosis in vivo without the insertion of a transvaginal probe or fluorescence. In our talk, we will present the design of our system, compare and analyze our preliminary results, and discuss the feasibility of our approach in non-invasive in vivo detection of endometriosis.
Research and development of optical phantoms is a growing and popular field, but it suffers from the same inequities that exist in our overall healthcare system- the lack of research into optical phantoms that represent different skin tones, genders, and body types. We are developing a library of multilayered liquid and solid phantoms with vastly different light absorbing and light scattering properties at differing wavelengths, focusing particularly on the optical properties of the uterine tissue. Our multilayer phantoms mimicking the pelvic region where the uterus lies also incorporate various properties that replicate different thicknesses of adipose tissue and skin pigmentation.
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