Ms. Galina A. Cherevatenko Profile

Galina A. Cherevatenko

at Peter the Great Saint-Petersburg Polytechnic Univ

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Proceedings Article | 30 January 2014 Paper

Research and development of a differential laser polarimeter to measure the glucose concentration in turbid media

Galina Cherevatenko, Evgenii Aksenov

Proceedings Volume 9031, 903105 (2014) https://doi.org/10.1117/12.2051017

KEYWORDS: Glucose, Polarimetry, Polarization, Blood, Scattering, Light scattering, Skin, Photodetectors, Tissues, Tissue optics

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Method of optical polarimetry is well known, but earlier it was mainly used to low scattering media. In this paper we consider the possibility of measuring the glucose concentration by detecting polarization of the backscattered laser light. As object of research a human finger have been chosen. The optimal parameters of the probing light were identified, degree of polarization of light scattered by human skin and model objects was registered. A laboratory model of a differential polarimeter, which allows to register the parameters of the polarized radiation scattered by human skin and glucose containing models, was developed. Using the developed polarimeter, model and full-scale experiments were carried out. In the model experiments we investigated the light backscattered by the following objects: a 20% solution of milk and a 50% suspension of human blood. During experiments it was shown, that the amount of optical rotation is also dependent on the angle of registration and, hence, photodetectors position in space is important. The ability of the developed sensor to noninvasively detect the concentration of glucose in the blood was demonstrated. However, its sensitivity to the structure of human skin and the individual characteristics of the organism was identified. This suggests that in order to achieve maximum accuracy it is necessary to carry out individual adjustment and calibration of measuring equipment.

Proceedings Article | 24 June 2013 Paper

Measurement of glucose concentration in turbid media by the polarization state of backscattered laser light

Galina Kafidova, Evgenii Aksenov, Victor Petrov

Proceedings Volume 8803, 880306 (2013) https://doi.org/10.1117/12.2032409

KEYWORDS: Glucose, Blood, Polarization, Light scattering, Skin, Polarimetry, Refractive index, Scattering, Plasma, Photodiodes

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Biological tissues, including human skin, are complex objects for optical measurements. Because of its multi-component structure, they are characterized by a combined response to various dynamic changes, both inside and outside of the biological object. Change of glucose concentration in the blood leads to a number of processes, which affect the light scattering properties of the skin and subcutaneous layers, herewith scattering coefficient and the polarization of the scattered light vary. The possibility of non-invasive blood glucose detection by parameters of backscattered laser light was experimentally demonstrated. Degree of polarization of light scattered by human skin and model objects was registered and dependence of the polarization state of backscattered radiation on the glucose concentration in the human blood was shown. A laboratory model of a differential polarimeter, which allows registering the parameters of the polarized radiation scattered by human skin and glucose containing models was developed. Using the developed model, model and full-scale experiments were conducted. In the model experiments, the light scattered in the forward and backwards direction by the following model objects: a 20% solution of milk and a 50% solution of whole human blood was investigated. The ability of the developed sensor to noninvasively detect the concentration of glucose in the blood was demonstrated.

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