Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that severely impacts quality of life, so biomarkers that help identify AD are highly sought after. Here, we investigated the retinas of APPSL and 5xFAD mouse models and wild-type littermate controls, provided by QPS Austria GmbH, using a custom optical coherence tomography (OCT) ophthalmoscope. Features of interest including retinal thickness, the visibility of the photoreceptor inner and outer segment junction, and vessel density were quantified from the OCT images, with a number of significant differences between groups. This study identifies potential AD biomarkers and reemphasizes the importance of using proper age-matched controls.
Alzheimer’s Disease (AD) is a degenerative neurological condition. Here, we use polarization-sensitive optical coherence tomography to characterize APPSL and 5xFAD mouse models for AD research. It was observed at approximately one year of age, both control and transgenic mice had developed similar retinal features, but AD models demonstrated significantly higher counts of hyperscattering foci compared to controls and some 5xFAD mice demonstrated a thickening of the photoreceptor layers. This study identifies potential AD biomarkers and reemphasizes the importance of using proper age-matched controls for animal studies, particularly when studying age-dependent diseases such as AD.
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