Purpose: Radiomics have become invaluable for non-invasive cancer patient risk prediction, and the community now turns to exogenous assessment, e.g., from genomics, for interpretability of these agnostic analyses. Yet, some opportunities for clinically interpretable modeling of positron emission tomography (PET) imaging data remain unexplored, that could facilitate insightful characterization at voxel level.Approach: Here, we present a novel deformable tubular representation of the distribution of tracer uptake within a volume of interest, and derive interpretable prognostic summaries from it. This data-adaptive strategy yields a 3D-coherent and smooth model fit, and a profile curve describing tracer uptake as a function of voxel location within the volume. Local trends in uptake rates are assessed at each voxel via the calculation of gradients derived from this curve. Intratumoral heterogeneity can also be assessed directly from it.Results: We illustrate the added value of this approach over previous strategies, in terms of volume rendering and coherence of the structural representation of the data. We further demonstrate consistency of the implementation via simulations, and prognostic potential of heterogeneity and statistical summaries of the uptake gradients derived from the model on a clinical cohort of 158 sarcoma patients imaged with F18-fluorodeoxyglucose–PET, in multivariate prognostic models of patient survival.Conclusions: The proposed approach captures uptake characteristics consistently at any location, and yields a description of variations in uptake that holds prognostic value complementarily to structural heterogeneity. This creates opportunities for monitoring of local areas of greater interest within a tumor, e.g., to assess therapeutic response in avid locations.
Intratumoral heterogeneity biomarkers derived from positron emission tomography (PET) imaging with fluorodeoxyglucose (FDG) are of interest for a number of cancers, including sarcoma. A range of radiomic texture variables, adapted from general methodologies for image analysis, has shown promise in the setting. In the context of sarcoma, our group introduced an alternative model-based approach to the measurement of heterogeneity. In this approach, the heterogeneity of a tumor is characterized by the extent to which the 3-D FDG uptake pattern deviates from a simple elliptically contoured structure. By using a nonparametric analysis of the uptake profile obtained from this spatial model, a variable assessing the metabolic gradient of the tumor is developed. The work explores the prognostic potential of this new variable in the context of FDG-PET imaging of sarcoma. A mature clinical series involving 197 patients, 88 of whom have complete time-to-death information, is used. Texture variables based on the imaging data are also evaluated in this series and a range of appropriate machine learning methodologies are then used to explore the complementary prognostic roles for structure and texture variables. We conclude that both texture-based and model-based variables can be combined to achieve enhanced prognostic assessments of outcome for patients with sarcoma based on FDG-PET imaging information.
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