The formation of a monolayer and its structure depend on many factors. One of the least studied factors is the influence of the electric field. In this regard, the purpose of this study is to investigate the influence of the direction and magnitude of the electric field on the properties of monolayer, formed on the surface of water. The experiments have revealed: the electric field exerts a significant influence on the formation of monolayers, in particular, during liquid phase formation. The second part of the isotherm (corresponding liquid phase) were significantly stretched. We explain the liquid phase extension by the fact of the charge increasing (and change pH) of the surface region. To confirm this assumption also we made computer modelling of process monolayer formation.
Object of study: Improvement of life quality of patients with high stroke risk ia the main goal for development of system for patient-specific modeling of cardiovascular system. This work is dedicated at increase of safety outcomes for surgical treatment of brain blood supply alterations. The objects of study are common carotid artery, internal and external carotid arteries and bulb. Methods: We estimated mechanical properties of carotid arteries tissues and patching materials utilized at angioplasty. We studied angioarchitecture features of arteries. We developed and clinically adapted computer biomechanical models, which are characterized by geometrical, physical and mechanical similarity with carotid artery in norm and with pathology (atherosclerosis, pathological tortuosity, and their combination). Results: Collaboration of practicing cardiovascular surgeons and specialists in the area of Mathematics and Mechanics allowed to successfully conduct finite-element modeling of surgical treatment taking into account various features of operation techniques and patching materials for a specific patient. Numerical experiment allowed to reveal factors leading to brain blood supply decrease and atherosclerosis development. Modeling of carotid artery reconstruction surgery for a specific patient on the basis of the constructed biomechanical model demonstrated the possibility of its application in clinical practice at approximation of numerical experiment to the real conditions.
Object of study: Improvement of life quality of patients with high stroke risk ia the main goal for development of system for patient-specific modeling of cardiovascular system. This work is dedicated at increase of safety outcomes for surgical treatment of brain blood supply alterations. The objects of study are common carotid artery, internal and external carotid arteries and bulb. Methods: We estimated mechanical properties of carotid arteries tissues and patching materials utilized at angioplasty. We studied angioarchitecture features of arteries. We developed and clinically adapted computer biomechanical models, which are characterized by geometrical, physical and mechanical similarity with carotid artery in norm and with pathology (atherosclerosis, pathological tortuosity, and their combination). Results: Collaboration of practicing cardiovascular surgeons and specialists in the area of Mathematics and Mechanics allowed to successfully conduct finite-element modeling of surgical treatment taking into account various features of operation techniques and patching materials for a specific patient. Numerical experiment allowed to reveal factors leading to brain blood supply decrease and atherosclerosis development. Modeling of carotid artery reconstruction surgery for a specific patient on the basis of the constructed biomechanical model demonstrated the possibility of its application in clinical practice at approximation of numerical experiment to the real conditions.
An original methodology is developed for scanning of the arterial intima morphology using the atomic force microscopy. The probing nanolaboratory NTEGRASpectra (NT-MDT, Russia) was itilized. The pictures of the coronary artery intima topology were obtained with the resolution of 1 nm. The 3D model of the ‘endothelial cell surface - low density lipoprotein (LDL)’ complex was constructed. Using the ANSYS software, the deformation of LDL particle was found as well as the stress distribution at the moment of the macromolecule and endothelial surface collision. The largest normal and tangential stresses are found in the area of LDL interaction with the surface. These stresses are 2.173 and 0.053 kPa, respectively. It was shown that the LDL structure is being highly strained, which leads to the molecule compression and crease. Therefore, one can conclude that at the moment of LDL entering the intercellular hiatus the macromolecule will be suffering the overall deformations and large modification of its structure.
Different types of carbon nanotube + graphene quantum dot composites were investigated. Stable configuration of
carbon nanotube + graphene quantum dot composites with the van der Waals and the chemical interactions were
established. It was shown that a peapod + graphene quantum dot (GQD) composite is a stable configuration at the
chemical interaction. Investigation of the stability were performed by means of the empirical method based on Brenner's
potential. The ionization potential of the peapod + GQD composite decreases by 0.5% in comparison with the ionization
potential of the hollow nanotubes.
We studied the phospholipid molecule structure, rigidity, rotary mobility and micelle aggregation process using a coarse-grained
(CG) model. It was found that the phospholipid structure can be presented as a spring with a rigidity of 27.68
kN/m. The rotational frequency of such molecule equals to 0.9 GHz at the temperature of 293 K and increases up to 1.2
GHz at 309K. At the constant temperature the micelle aggregation time does not depend on number of interacting
molecules. Along with the temperature increase, the aggregation time decreases. At lower temperatures the assembly
process depends on distance between the adjacent molecules.
The results of quantum-chemical analysis of elastic and strength properties of the bamboo-like tube are presented in this
paper. For the first time the configuration of the thinnest stable bamboo-like tube was established. The bamboo-like
nanotube breaking point is established to be under compression of 11GPa. Configuration of the nanoindentor based on
symmetric and streamlined tip of the tube (15,15), presented in this work, provides perfect interaction between the
nanoindentor tip and the tissue because tip has no sharp protruding pieces.
We report the results of the chitosan dimer study, the mechanism of its interaction with the carbon nanostructures and
also the mechanical properties of the chitosan/graphene, chitosan/nanotube complexes using the density function and
the molecular dynamic methods. It was established that the physical adsorption of the chitosan with graphene is carried
out by the Van der Waals interaction between the hexagonal links of the chitosan with the hexagonal cell of the atomic
grid of graphene and nanotube.
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