Optically induced hyperthermia is an actively developing approach to treating cancer. All-dielectric nanoparticles have established themselves in different biomedical applications, including optical heating and nanothermometry. However, this type of nanoparticles (NPs) do not provide sufficient heating due to the necessity for a narrow size distribution. Thus, size-separation is required. Other method of negating disadvantages of all-dielectric NPs is incorporating plasmonic nanoparticles to create hybrid nanostructure, which would be less sensitive to size distribution, making it great nanoheater and nanothermometer. In this work, we propose a simple way of fabricating hybrid silicon-gold (Si-Au) NPs. We compare hybrid nanoparticles with pristine monodisperse Si NPs. In addition, we perform optical heating and simultaneous nanothermometry inside and outside living B16-F10 melanoma cells. Results reveal, that the hybrid NPs are more efficient in biological environments, since inhomogeneous medium can make it difficult to fulfill the critical coupling conditions.
Accurate thermal monitoring is essential tool for photothermal therapy or for application light-responsive drug delivery platforms, because overheating of living cells is related with unwanted side effects in surrounding tissues. In this work, we investigated a multifunctional polymer capsule embedded with nitrogen vacancies (NV) centers as nanothermometers and gold (Au) nanoparticles (NPs) as heating agents to perform of laser-induced release of bioactive compounds from the carriers with a simultaneous temperature measurements inside living cells.
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