Dr. Dongyao Cui Profile

Dr. Dongyao Cui

at Massachusetts General Hospital

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Author

Publications (7)

Proceedings Article | 29 April 2017 Open Access

Optical coherence tomography multichannel probe design for speckle reduction (Withdrawal Notice)

Dongyao Cui, En Bo, Yuemei Luo, Xinyu Liu, Xianghong Wang, Si Chen, Xiaojun Yu, Shi Chen, Ping Shum, Linbo Liu

Proceedings Volume 10340, 103401E (2017) https://doi.org/10.1117/12.2271547

KEYWORDS: Speckle, Optical coherence tomography, Biomedical optics, Signal to noise ratio, Image resolution, Esophagus, Tissues, Spectroscopy, Image quality, Polishing, Yield improvement, Silicon

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Proceedings Article | 20 April 2017 Paper

Towards a clinical implementation of uOCT instrument for in vivo imaging of human airways

Hui Min Leung, Dongyao Cui, Timothy Ford, Daryl Hyun, Jing Dong, Biwei Yin, Susan Birket, George Solomon, Linbo Liu, Steven Rowe, Guillermo Tearney

Proceedings Volume 10056, 1005614 (2017) https://doi.org/10.1117/12.2253423

KEYWORDS: Liquids, Pathogens, Human subjects, Imaging systems, Optical coherence tomography, Coherence (optics), Tomography, In vivo imaging, Cystic fibrosis, Image resolution

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Proceedings Article | 19 April 2017 Presentation

Imaging demonstration of a flexible micro-OCT endobronchial probe (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Timothy Ford, Daryl Chulho Hyun, Hui Min Leung, Biwei Yin, Susan Birket, George Solomon, Steven Rowe, Guillermo Tearney

Proceedings Volume 10041, 1004109 (2017) https://doi.org/10.1117/12.2251449

KEYWORDS: Imaging systems, Photomedicine, Optical coherence tomography, Cystic fibrosis, Chronic obstructive pulmonary disease, In vivo imaging, Visualization, Motion models, Performance modeling, Imaging devices

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Proceedings Article | 27 April 2016 Presentation

Flexible micro-OCT endobronchial probe for imaging of mucociliary transport (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Carolin Unglert, Tim Ford, Robert Carruth, Daryl Hyun, Kanwarpal Singh, Susan Birket, George Solomon, Steve Rowe, Guillermo Tearney

Proceedings Volume 9691, 969107 (2016) https://doi.org/10.1117/12.2213057

KEYWORDS: Visualization, Cystic fibrosis, Chronic obstructive pulmonary disease, Pathogens, In vivo imaging, Photomedicine, Imaging systems, Particles, Lung, Liquids

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Mucociliary clearance (MCC) plays a significant role in maintaining the health of human respiratory system by eliminating foreign particles trapped within mucus. Failure of this mechanism in diseases such as cystic fibrosis and chronic obstructive pulmonary disease (COPD) leads to airway blockage and lung infection, causing morbidity and mortality. The volume of airway mucus and the periciliary liquid encapsulating the cilia, in addition to ciliary beat frequency and velocity of mucociliary transport, are vital parameters of airway health. However, the diagnosis of disease pathogenesis and advances of novel therapeutics are hindered by the lack of tools for visualization of ciliary function in vivo. Our laboratory has previously developed a 1-µm resolution optical coherence tomography method, termed Micro-OCT, which is capable of visualizing mucociliary transport and quantitatively capturing epithelial functional metrics. We have also miniaturized Micro-OCT optics in a first-generation rigid 4mm Micro-OCT endoscope utilizing a common-path design and an apodizing prism configuration to produce an annular profile sample beam, and reported the first in vivo visualization of mucociliary transport in swine. We now demonstrate a flexible 2.5 mm Micro-OCT probe that can be inserted through the instrument channel of standard flexible bronchoscopes, allowing bronchoscopic navigation to smaller airways and greatly improving clinical utility. Longitudinal scanning over a field of view of more than 400 µm at a frame rate of 40 Hz was accomplished with a driveshaft transduced by a piezo-electric stack motor. We present characterization and imaging results from the flexible micro-OCT probe and progress towards clinical translation. The ability of the bronchoscope-compatible micro-OCT probe to image mucus clearance and epithelial function will enable studies of cystic fibrosis pathogenesis in small airways, provide diagnosis of mucociliary clearance disorders, and allow individual responses to treatments to be monitored.

Proceedings Article | 27 April 2016 Presentation

Mechanical modeling of cholesterol crystallization in atherosclerotic plaques base on Micro-OCT images (Conference Presentation)

Yuemei Luo, Xinyu Liu, Si Chen, Dongyao Cui, Xianghong Wang, Linbo Liu

Proceedings Volume 9689, 96892P (2016) https://doi.org/10.1117/12.2209247

KEYWORDS: Crystals, Crystallography, Tomography, Spatial resolution, Arteries, Blood pressure, Photonic crystals, Silicon, Image processing, Diagnostics

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Proceedings Article | 26 April 2016 Presentation

Spectral estimation optical coherence tomography for axial super-resolution (Conference Presentation)

Xinyu Liu, Xiaojun Yu, Nanshuo Wang, En Bo, Yuemei Luo, Si Chen, Dongyao Cui, Linbo Liu

Proceedings Volume 9697, 96970Q (2016) https://doi.org/10.1117/12.2211307

KEYWORDS: Optical coherence tomography, Signal to noise ratio, Super resolution, Fourier transforms, Cornea, Statistical analysis, Reflectivity, Light sources, Spectral resolution, Particles

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Proceedings Article | 2 March 2015 Paper

One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging

Dongyao Cui, Xinyu Liu, Jing Zhang, Xiaojun Yu, Ding Sun, Yuemei Luo, Jun Gu, Ping Shum, Linbo Liu

Proceedings Volume 9312, 93123R (2015) https://doi.org/10.1117/12.2076438

KEYWORDS: Cameras, Optical coherence tomography, In vivo imaging, Signal to noise ratio, Image resolution, Imaging systems, Mirrors, Electrons, Spectral resolution, Near infrared

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Showing 5 of 7 publications

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