A challenge within the motor biophysics field is reconstituting a motor-filament environment that reflects physiological function. Many optical trapping studies of motor proteins employ a reductionist geometry of a single motor interacting with a single filament. These conformations do not accurately represent the structural architecture in which motors with crosslinking ability, such as myosins or mitotic kinesins, function. Thus, we engineered customizable “nanocells” of reconstituted protein assemblies to probe hierarchical cytoskeletal mechanics with high resolution using optical tweezers.
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