The ability to monitor disease progression over time is critical to inform patient care and prognosis, especially in usual interstitial pneumonia (UIP), the histopathological pattern seen in idiopathic pulmonary fibrosis (IPF). HRCT is limited in resolution to detect disease changes on a microscopic level, and surgical lung biopsy (SLB) has high risk of morbidity and mortality precluding its use to assess progression. Endobronchial optical coherence tomography (EB-OCT) is a bronchoscopic, minimally-invasive, high-resolution imaging method that accurately detects microscopic ILD features and is repeatable. Here, we evaluate the utility of repeat EB-OCT for monitoring microscopic disease progression in UIP/IPF.
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