Dr. Anna Khimchenko Profile

Dr. Anna Khimchenko

Medical science liaison at Mimosa Diagnostics

SPIE Involvement:

Conference Program Committee | Author | Career Lab Leader

Websites:

Company Website

Profile Summary

Dr. Anna Khimchenko is an experienced diagnostic imaging scientist and science communicator with a strong background in the medical device industry. With over 10 years of international experience in commercial development, market access, and med-tech R&D, she is well-versed in driving innovation in healthcare.

Anna earned her Ph.D. in Medical Science from the University of Basel, Switzerland, focusing on tomographic imaging and brain neurodegeneration. She furthered her expertise through postdoctoral training in Dermatology at Harvard Medical School and Massachusetts General Hospital, specializing in optical coherence tomography and cystic fibrosis.

Drawing on her extensive experience in translational research and healthcare innovation, Anna has made significant contributions to fields including wounds, sepsis, antimicrobial resistance, oncology, and neurology/neurodegeneration. Her expertise and dedication make her a valuable asset in advancing medical science and improving patient care.

As a Medical Science Liaison at Mimosa Diagnostics in Toronto, Anna serves as a pivotal conduit between cutting-edge medical technology and the healthcare sector, effectively connecting innovative solutions with key stakeholders.

Publications (16)

Proceedings Article | 8 July 2021 Open Access

Open Access

Paper

X-ray imaging of human brain tissue down to the molecule level

Bert Müller, Anna Khimchenko, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Georg Schulz

Proceedings Volume 11886, 1188613 (2021) https://doi.org/10.1117/12.2592603

Read Abstract +

X rays have been used for medical imaging since RÖNTGEN's fascinating discovery 125 years ago. The first radiographs of human hands were made public less than a month after his famous paper. The conventional X-ray sources integrated into the CT-machines of today’s hospitals still rely on the same physical principles. X-ray imaging has traditionally offered high spatial resolution and low contrast for soft tissues such as the brain. Magnetic resonance imaging is therefore the method of choice for brain imaging in a clinical setting, although for cellular resolution studies it suffers from limited spatial resolution. The gold standard in post mortem brain imaging is histology, which involves fixation, embedding, physical sectioning, staining, and optical microscopy. Currently, section thickness limits isotropic voxel sizes to 20 μm. Advanced X-ray sources including synchrotron radiation facilities offer complementary modalities such as phase-contrast imaging and spatially resolved small-angle X-ray scattering. We showed that X-ray phase contrast of the human cerebellum with micrometer resolution yields complementary three-dimensional images to magnetic resonance microscopy with even better contrast and spatial resolution. Grating interferometry enabled us to visualize individual Purkinje cells in the nonstained cerebellum. Taking advantage of well-established paraffin embedding, Purkinje cells were visualized within the human cerebellum even with conventional instrumentation. Hard X-ray nano-holotomography allowed for label-free, three-dimensional neuroimaging beyond the optical limit with a spatial resolution below 100 nm. Spatially resolved smallangle X-ray scattering permitted the localization of periodic nanostructures such as myelin sheaths on square-inch brain slices and included the orientational information on the axons. These developments have contributed to the establishment of virtual histology and extended the conventional histology to the third dimension. Further advances are required to image the entire human brain with an isotropic micrometer resolution and to suitably handle the petabyte datasets.

Proceedings Article | 5 March 2021 Presentation

Presentation

Advancement of magnetomotive micro optical coherence tomography (μOCT) microrheology for probing mucus viscoelastic properties

Linhui Yu, Anna Khimchenko, Hui Min Leung, Susan Birket, Steven Rowe, Guillermo Tearney

Proceedings Volume 11647, 1164712 (2021) https://doi.org/10.1117/12.2576335

KEYWORDS: Optical coherence tomography, Magnetism, Scattering, Interfaces, Data acquisition, Cystic fibrosis

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Proceedings Article | 6 October 2017 Paper

Paper

Grating-based tomography applications in biomedical engineering

Georg Schulz, Peter Thalmann, Anna Khimchenko, Bert Müller

Proceedings Volume 10391, 1039117 (2017) https://doi.org/10.1117/12.2274244

KEYWORDS: Interferometers, X-rays, Tomography, Tissues, Spatial resolution, Visualization, X-ray sources, Biomedical engineering, Interferometry

Read Abstract +

Proceedings Article | 26 September 2017 Paper

Paper

Innervation of the cow’s inner ear derived from micro-computed tomography

Loic Costeur, Bastien Mennecart, Anna Khimchenko, Bert Müller, Georg Schulz

Proceedings Volume 10391, 103911I (2017) https://doi.org/10.1117/12.2276158

KEYWORDS: Nerve, Ear, Bone, Sensors, Tomography, Acoustics, X-ray sources, Computed tomography, Skull, X-ray technology

Read Abstract +

Proceedings Article | 25 September 2017 Paper

Paper

Imaging cellular and subcellular structure of human brain tissue using micro computed tomography

Anna Khimchenko, Christos Bikis, Gabriel Schweighauser, Jürgen Hench, Alexandra-Teodora Joita-Pacureanu, Peter Thalmann, Hans Deyhle, Bekim Osmani, Natalia Chicherova, Simone Hieber, Peter Cloetens, Magdalena Müller-Gerbl , Georg Schulz, Bert Müller

Proceedings Volume 10391, 103910K (2017) https://doi.org/10.1117/12.2274120

KEYWORDS: Tomography, Tissues, Brain, Microscopy, Spatial resolution, Computed tomography, Cerebellum, Visualization, Optical microscopy, X-rays

Read Abstract +

Proceedings Article | 17 April 2017 Presentation + Paper

Presentation + Paper

Three-dimensional imaging of human brain tissues using absorption-contrast high-resolution X-ray tomography

Anna Khimchenko, Georg Schulz, Christos Bikis, Hans Deyhle, Natalia Chicherova, Simone Hieber, Gabriel Schweighauser, Jürgen Hench, Bert Müller

Proceedings Volume 10162, 101620K (2017) https://doi.org/10.1117/12.2259977

KEYWORDS: Tissues, Absorption, Tomography, Brain, Phase contrast, Visualization, X-ray imaging, X-rays, Computed tomography, Hard x-rays, Cerebellum, 3D image processing, Data modeling, Neuroimaging

Read Abstract +

Proceedings Article | 21 October 2016 Presentation + Paper

Presentation + Paper

Automatic histology registration in application to x-ray modalities

Natalia Chicherova, Simone Hieber, Georg Schulz, Anna Khimchenko, Christos Bikis, Philippe Cattin, Bert Müller

Proceedings Volume 9967, 996708 (2016) https://doi.org/10.1117/12.2237322

KEYWORDS: Image registration, Tomography, X-rays, X-ray imaging, X-ray computed tomography, 3D image processing, Sensors, Clouds, Detection and tracking algorithms, Interferometry

Read Abstract +

Proceedings Article | 4 October 2016 Paper

Paper

Hierarchical imaging of the human knee

Georg Schulz, Christian Götz, Hans Deyhle, Magdalena Müller-Gerbl, Irene Zanette, Marie-Christine Zdora, Anna Khimchenko, Peter Thalmann, Alexander Rack, Bert Müller

Proceedings Volume 9967, 99670R (2016) https://doi.org/10.1117/12.2238089

KEYWORDS: Visualization, Cartilage, X-ray computed tomography, Bone, X-rays, Computed tomography, Spatial resolution, Tissues, Diamond, Light sources

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Proceedings Article | 4 October 2016 Presentation + Paper

Presentation + Paper

X-ray micro-tomography for investigations of brain tissues on cellular level

Anna Khimchenko, Georg Schulz, Hans Deyhle, Peter Thalmann, Irene Zanette, Marie-Christine Zdora, Christos Bikis, Alexander Hipp, Simone Hieber, Gabriel Schweighauser, Jürgen Hench, Bert Müller

Proceedings Volume 9967, 996703 (2016) https://doi.org/10.1117/12.2237554

KEYWORDS: Tissues, Phase contrast, Visualization, X-rays, Brain, Interferometry, Absorption, Tomography, Synchrotron radiation, Cerebellum

Read Abstract +

X-ray imaging in absorption contrast mode is well established for hard tissue visualization. However, performance for lower density materials is limited due to a reduced contrast. Our aim is three-dimensional (3D) characterization of micro-morphology of human brain tissues down to (sub-)cellular resolution within a laboratory environment. Using the laboratory-based microtomography (μCT) system nanotom m (GE Sensing and Inspection Technologies GmbH, Wunstorf, Germany) and synchrotron radiation at the Diamond-Manchester Imaging Branchline I13-2 (Diamond Light Source, Didcot, UK), we have acquired 3D data with a resolution down to 0.45 μm for visualization of a human cerebellum specimen down to cellular level. We have shown that all selected modalities, namely laboratory-based absorption contrast micro-tomography (LBμCT), synchrotron radiation based in-line single distance phase contrast tomography (SDPR) and synchrotron radiation based single-grating interferometry (GI), can reach cellular resolution for tissue samples with a size in the mm-range. The results are discussed qualitatively in comparison to optical microscopy of haematoxylin and eosin (HE) stained sections. As phase contrast yields to a better data quality for soft tissues and in order to overcome restrictions of limited beamline access for phase contrast measurements, we have equipped the μCT system nanotom m with a double-grating phase contrast set-up. Preliminary experimental results of a knee sample consisting of a bony part and a cartilage demonstrate that phase contrast data exhibits better quality compared to absorption contrast. Currently, the set-up is under adjustment. It is expected that cellular resolution would also be achieved. The questions arise (1) what would be the quality gain of laboratory-based phase contrast in comparison to laboratory-based absorption contrast tomography and (2) could laboratory-based phase contrast data provide comparable results to synchrotron radiation based phase contrast data.

Proceedings Article | 3 October 2016 Paper

Paper

Computational cell quantification in the human brain tissues based on hard x-ray phase-contrast tomograms

Simone Hieber, Christos Bikis, Anna Khimchenko, Georg Schulz, Hans Deyhle, Peter Thalmann, Natalia Chicherova, Alexander Rack, Marie-Christine Zdora, Irene Zanette, Gabriel Schweighauser, Jürgen Hench, Bert Müller

Proceedings Volume 9967, 99670K (2016) https://doi.org/10.1117/12.2237012

KEYWORDS: Tissues, Visualization, Cerebellum, Tomography, 3D image processing, Brain, Image segmentation, Edge detection, Neuroimaging, Light sources

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Proceedings Article | 3 October 2016 Paper

Paper

Histology-validated x-ray tomography for imaging human coronary arteries

Marzia Buscema, Georg Schulz, Hans Deyhle, Anna Khimchenko, Sofiya Matviykiv, Margaret Holme, Alexander Hipp, Felix Beckmann, Till Saxer, Katarzyna Michaud, Bert Müller

Proceedings Volume 9967, 99670O (2016) https://doi.org/10.1117/12.2238702

KEYWORDS: Tissues, Arteries, Absorption, Tomography, Phase contrast, X-rays, X-ray imaging, Heart, Visualization, Data acquisition

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Proceedings Article | 3 October 2016 Paper

Paper

High-resolution synchrotron radiation-based phase tomography of the healthy and epileptic brain

Christos Bikis, Philipp Janz, Georg Schulz, Gabriel Schweighauser, Jürgen Hench, Peter Thalmann, Hans Deyhle, Natalia Chicherova, Alexander Rack, Anna Khimchenko, Simone Hieber, Luigi Mariani, Carola Haas, Bert Müller

Proceedings Volume 9967, 996706 (2016) https://doi.org/10.1117/12.2237816

KEYWORDS: Brain, Tomography, Epilepsy, Visualization, Neuroimaging, Synchrotrons, Tissues, 3D modeling, Animal model studies, X-rays

Read Abstract +

Proceedings Article | 3 October 2016 Presentation + Paper

Presentation + Paper

Imaging tissues for biomedical research using the high-resolution micro-tomography system nanotom(r) m

Hans Deyhle, Georg Schulz, Anna Khimchenko, Christos Bikis, Simone Hieber, Claude Jaquiery, Christoph Kunz, Magdalena Müller-Gerbl, Sebastian Höchel, Till Saxer, Anja Stalder, Bernd Ilgenstein, Felix Beckmann, Peter Thalmann, Marzia Buscema, Nadja Rohr, Margaret Holme, Bert Müller

Proceedings Volume 9967, 99670Q (2016) https://doi.org/10.1117/12.2237809

KEYWORDS: Tissues, Medical research, Biomedical optics, Visualization, Teeth, Bone, Signal attenuation, Imaging systems, Spatial resolution, Arteries

Read Abstract +

Proceedings Article | 22 April 2016 Paper

Paper

Non-destructive phase contrast hard x-ray imaging to reveal the three-dimensional microstructure of soft and hard tissues

Anna Khimchenko, Georg Schulz, Hans Deyhle, Simone Hieber, Samiul Hasan, Christos Bikis, Joachim Schulz, Loïc Costeur, Bert Müller

Proceedings Volume 9797, 97970B (2016) https://doi.org/10.1117/12.2222038

KEYWORDS: Phase contrast, Tissues, Visualization, Visibility, Absorption, X-rays, Tomography, Hard x-rays, Interferometers, Biomimetics

Read Abstract +

Proceedings Article | 9 October 2014 Paper

Paper

Three-dimensional imaging of human hippocampal tissue using synchrotron radiation- and grating-based micro computed tomography

Simone Hieber, Anna Khimchenko, Christopher Kelly, Luigi Mariani, Peter Thalmann, Georg Schulz, Rüdiger Schmitz, Imke Greving, Marco Dominietto, Bert Müller

Proceedings Volume 9212, 92120S (2014) https://doi.org/10.1117/12.2061582

KEYWORDS: Tissues, Phase measurement, Phase contrast, Epilepsy, Image segmentation, Brain, Computed tomography, Tomography, Image filtering, Interferometry

Read Abstract +

Proceedings Article | 19 September 2014 Paper

Paper

Three-dimensional registration of synchrotron radiation-based micro-computed tomography images with advanced laboratory micro-computed tomography data from murine kidney casts

Peter Thalmann, Simone Hieber, Georg Schulz, Hans Deyhle, Anna Khimchenko, Vartan Kurtcuoglu, Ufuk Olgac, Anastasios Marmaras, Willy Kuo, Eric Meyer, Felix Beckmann, Julia Herzen, Stefanie Ehrbar, Bert Müller

Proceedings Volume 9212, 92120Y (2014) https://doi.org/10.1117/12.2060809

KEYWORDS: Tomography, Kidney, Image registration, 3D image processing, Signal attenuation, Rigid registration, Synchrotrons, Corrosion, Signal to noise ratio, Image segmentation

Read Abstract +

Showing 5 of 16 publications

Conference Committee Involvement (5)

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII

29 January 2024 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXI

30 January 2023 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX

24 January 2022 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX

6 March 2021 | Online Only, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII

3 February 2020 | San Francisco, California, United States

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