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12 August 2015 In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection
Yong Zhou, Joemini Poudel, Guo Li, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 20, Issue 8, 087001 (August 2015). https://doi.org/10.1117/1.JBO.20.8.087001
Abstract
We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first demonstrated our method in phantom experiments, where a root mean square error of prediction of 0.29  mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depths, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Yong Zhou, Joemini Poudel, Guo Li, and Lihong V. Wang "In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection," Journal of Biomedical Optics 20(8), 087001 (12 August 2015). https://doi.org/10.1117/1.JBO.20.8.087001
Published: 12 August 2015
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Cited by 4 scholarly publications and 1 patent.
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KEYWORDS
Blood circulation
Velocity measurements
In vivo imaging
Blood
Blood vessels
Acquisition tracking and pointing
Tissue optics
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