In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection

Yong Zhou; Joemini Poudel; Guo Li; Lihong V. Wang

doi:10.1117/12.2217468

15 March 2016 In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection

Yong Zhou, Joemini Poudel, Guo Li, Lihong V. Wang

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97084U (2016) https://doi.org/10.1117/12.2217468
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We propose a saline-injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline-blood-interface propagating in the blood vessel, we can resolve the flow velocity. In phantom experiments, a root-mean-squared error of prediction of 0.29 mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depth, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.

Citation Download Citation

Yong Zhou, Joemini Poudel, Guo Li, and Lihong V. Wang "In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084U (15 March 2016); https://doi.org/10.1117/12.2217468

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