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21 December 2015 Photoacoustic tomography of vascular compliance in humans
Pengfei Hai, Yong Zhou, Jinyang Liang, Chiye Li, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 20, Issue 12, 126008 (December 2015). https://doi.org/10.1117/1.JBO.20.12.126008
Abstract
Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT’s potential for clinical thrombosis detection.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Pengfei Hai, Yong Zhou, Jinyang Liang, Chiye Li, and Lihong V. Wang "Photoacoustic tomography of vascular compliance in humans," Journal of Biomedical Optics 20(12), 126008 (21 December 2015). https://doi.org/10.1117/1.JBO.20.12.126008
Published: 21 December 2015
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Cited by 25 scholarly publications.
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KEYWORDS
Blood vessels
Image compression
Photoacoustic spectroscopy
Photoacoustic tomography
Tissue optics
Tissues
Acquisition tracking and pointing
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