Computational scattered light imaging for label-free visualization of fiber architecture in tumor tissues

Hamed Abbasi; Loes Ettema; Michail Doukas; Sjors Koppes; Stijn Keereweer; Miriam Menzel

doi:10.1117/12.3017035

20 June 2024 Computational scattered light imaging for label-free visualization of fiber architecture in tumor tissues

Hamed Abbasi, Loes Ettema, Michail Doukas, Sjors Koppes, Stijn Keereweer, Miriam Menzel

Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC130060A (2024) https://doi.org/10.1117/12.3017035
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Studying fiber architectures in tumor tissues is of great importance as the cancer cells interact with fiber structures in the Extracellular Matrix (ECM). Computational Scattered Light Imaging (ComSLI) represents an innovative, non-destructive approach to whole-slide imaging with micrometer resolution, uniquely capable of accurately unraveling the complex, intertwined fiber structures in biological tissues. So far, it has been mainly used to study highly interwoven nerve fiber architectures in brain tissues. In this study, we extend the application of ComSLI to visualize fibers in diverse tumor tissues, including oral squamous cell carcinoma (OSCC) and colorectal cancer.

Conference Presentation

Citation Download Citation

Hamed Abbasi, Loes Ettema, Michail Doukas, Sjors Koppes, Stijn Keereweer, and Miriam Menzel "Computational scattered light imaging for label-free visualization of fiber architecture in tumor tissues", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC130060A (20 June 2024); https://doi.org/10.1117/12.3017035

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