Monitoring the morphochemistry of laryngeal carcinoma by multimodal imaging

Tobias Meyer; Christoph Krafft; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Günther Ernst; Benjamin Dietzek; Jürgen Popp

doi:10.1117/12.906180

31 January 2012 Monitoring the morphochemistry of laryngeal carcinoma by multimodal imaging

Tobias Meyer, Christoph Krafft, Orlando Guntinas-Lichius, Ferdinand von Eggeling, Günther Ernst, Benjamin Dietzek, Jürgen Popp

Author Affiliations +

Proceedings Volume 8220, Optical Biopsy X; 82200R (2012) https://doi.org/10.1117/12.906180
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Multimodal nonlinear imaging constitutes a contemporary approach to investigate the morphochemistry of complex samples noninvasively and without administration of external labels. Here we discuss our recent success in jointly using various nonlinear microspectroscopic approaches such as coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence (TPF) and second-harmonic generation (SHG) to study the chemical composition of surgically removed tissue sections from laryngeal carcinoma. In particular it will be shown how multimodal nonlinear imaging can be employed to study the structural and chemical development of disease formation as well as to monitor the clinically important aspect of tumor boundary detection.

Citation Download Citation

Tobias Meyer, Christoph Krafft, Orlando Guntinas-Lichius, Ferdinand von Eggeling, Günther Ernst, Benjamin Dietzek, and Jürgen Popp "Monitoring the morphochemistry of laryngeal carcinoma by multimodal imaging", Proc. SPIE 8220, Optical Biopsy X, 82200R (31 January 2012); https://doi.org/10.1117/12.906180

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