Studying the effect of gluconeogenesis inhibitor drug on liver functionality using dynamic optical coherence tomography

Pradipta Mukherjee; Shinichi Fukuda; Donny Lukmanto; Kosuke Okada; Thi Hang Tran; Ibrahim Abd El-Sadek; Shuichi Makita; Yoshiaki Yasuno

doi:10.1117/12.3000670

13 March 2024 Studying the effect of gluconeogenesis inhibitor drug on liver functionality using dynamic optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Kosuke Okada, Thi Hang Tran, Ibrahim Abd El-Sadek, Shuichi Makita, Yoshiaki Yasuno

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Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC1284104 (2024) https://doi.org/10.1117/12.3000670
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present longitudinal functional activity imaging of liver functional zones in the presence of metabolic inhibitor drug with dynamic optical coherence tomography (DOCT). We studied a normal liver and a liver injected with metformin. In the normal liver, we found a correlation between the vascular structures observed in the DOCT and OCT projections. Over time, these vascular structures gradually decreased in the DOCT, while similar structures appeared in the OCT at a later time point. In the metformin-injected liver, we observed hexagonal liver lobule structures in the OCT. At late time point, several vessel-like structures with increased scattering appeared in the OCT, which were not initially present in the DOCT.

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Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Kosuke Okada, Thi Hang Tran, Ibrahim Abd El-Sadek, Shuichi Makita, and Yoshiaki Yasuno "Studying the effect of gluconeogenesis inhibitor drug on liver functionality using dynamic optical coherence tomography", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC1284104 (13 March 2024); https://doi.org/10.1117/12.3000670

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KEYWORDS

Liver

Optical coherence tomography

Animal model studies

3D projection

Coherence imaging

Imaging systems

Scattering

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