Polarized hyperspectral imaging system for in vivo detection of vulvar lichen sclerosis

Yingjie Qu; Wenqi Ren; Songde Liu; Peng Liu; Lan Xie; Xiaoyuan Zhang; Shiwu Zhang; Shufang Chang; Ronald Xu

doi:10.1117/12.2213802

4 March 2016 Polarized hyperspectral imaging system for in vivo detection of vulvar lichen sclerosis

Yingjie Qu, Wenqi Ren, Songde Liu, Peng Liu, Lan Xie, Xiaoyuan Zhang, Shiwu Zhang, Shufang Chang, Ronald Xu

Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97150Q (2016) https://doi.org/10.1117/12.2213802
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Vulvar lichen sclerosis (VLS) is a chronic, inflammatory and mucocutaneous disease of extragenital skin, which often goes undetected for years. The underlying causes are associated with the decrease of VEGF that reduces the blood oxygenation of vulva and the structural changes in the collagen fibrils, which can lead to scarring of the affected area. However, few methods are available for quantitative detection of VLS. Clinician’s examinations are subjective and may lead to misdiagnosis. Spectroscopy is a potentially effective method for noninvasive detection of VLS. In this paper, we developed a polarized, hyperspectral imaging system for quantitative assessment. The system utilized a hyperspectral camera to collect the reflectance images of the entire vulva under Xenon lamp illumination with and without a polarizer in front of the fiber. One image (I_par) acquired with the AOTF parallel to the polarization of illumination and the other image (I_per) acquired with the AOTF perpendicular to the illumination. This paper compares polarized images of VLS in a pilot clinical study. The collected reflectance data under Xenon lamp illumination without a polarizer are calibrated and the hyperspectral signals are extracted. An IRB approved clinical trial was carried out to evaluate the clinical utility for VLS detection. Our pilot study has demonstrated the technical potential of using this polarized hyperspectral imaging system for in vivo detection of vulvar lichen sclerosis.

Conference Presentation

Citation Download Citation

Yingjie Qu, Wenqi Ren, Songde Liu, Peng Liu, Lan Xie, Xiaoyuan Zhang, Shiwu Zhang, Shufang Chang, and Ronald Xu "Polarized hyperspectral imaging system for in vivo detection of vulvar lichen sclerosis", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150Q (4 March 2016); https://doi.org/10.1117/12.2213802

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