Nano-bio-optomechanics: nanoaperture tweezers probe single nanoparticles, proteins, and their interactions

Reuven Gordon

doi:10.1117/12.2193785

1 September 2015 Nano-bio-optomechanics: nanoaperture tweezers probe single nanoparticles, proteins, and their interactions

Reuven Gordon

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Proceedings Volume 9544, Metamaterials, Metadevices, and Metasystems 2015; 954403 (2015) https://doi.org/10.1117/12.2193785
Event: SPIE Nanoscience + Engineering, 2015, San Diego, California, United States

Abstract

Nanoparticles in the single digit nanometer range can be easily isolated and studied with low optical powers using nanoaperture tweezers. We have studied individual proteins and their interactions with small molecules, DNA and antibodies. Recently, using the fluctuations of the trapped object, we have pioneered a new way to "listen" to the vibrations of nanoparticles in the 100 GHz - 1 THz range; the approach is called extraordinary acoustic Raman (EAR). EAR gives unprecedented low frequency spectra of individual proteins in solution, allowing for identification and analysis, as well as probing their role in biological functions. We have also used EAR to study the elastic properties, shape and size of various individual nanoparticles.

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Reuven Gordon "Nano-bio-optomechanics: nanoaperture tweezers probe single nanoparticles, proteins, and their interactions", Proc. SPIE 9544, Metamaterials, Metadevices, and Metasystems 2015, 954403 (1 September 2015); https://doi.org/10.1117/12.2193785

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KEYWORDS

Proteins

Nanoparticles

Particles

Molecules

Optical tweezers

Raman spectroscopy

Acoustics

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