A relative quantitative assessment of myocardial perfusion by first-pass technique: animal study

Jun Chen; Zhang Zhang; Xuefang Yu; Kenneth J. Zhou

doi:10.1117/12.2083037

11 March 2015 A relative quantitative assessment of myocardial perfusion by first-pass technique: animal study

Jun Chen, Zhang Zhang, Xuefang Yu, Kenneth J. Zhou

Proceedings Volume 9315, Design and Quality for Biomedical Technologies VIII; 93150V (2015) https://doi.org/10.1117/12.2083037
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The purpose of this study is to quantitatively assess the myocardial perfusion by first-pass technique in swine model. Numerous techniques based on the analysis of Computed Tomography (CT) Hounsfield Unit (HU) density have emerged. Although these methods proposed to be able to assess haemodynamically significant coronary artery stenosis, their limitations are noticed. There are still needs to develop some new techniques. Experiments were performed upon five (5) closed-chest swine. Balloon catheters were placed into the coronary artery to simulate different degrees of luminal stenosis. Myocardial Blood Flow (MBF) was measured using color microsphere technique. Fractional Flow Reserve (FFR) was measured using pressure wire. CT examinations were performed twice during First-pass phase under adenosine-stress condition. CT HU Density (HUDCT) and CT HU Density Ratio (HUDRCT) were calculated using the acquired CT images. Our study presents that HUDRCT shows a good (y=0.07245+0.09963x, r²=0.898) correlation with MBF and FFR. In receiver operating characteristic (ROC) curve analyses, HUDR_CT provides excellent diagnostic performance for the detection of significant ischemia during adenosine-stress as defined by FFR indicated by the value of Area Under the Curve (AUC) of 0.927. HUDRCT has the potential to be developed as a useful indicator of quantitative assessment of myocardial perfusion.

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Jun Chen, Zhang Zhang, Xuefang Yu, and Kenneth J. Zhou "A relative quantitative assessment of myocardial perfusion by first-pass technique: animal study", Proc. SPIE 9315, Design and Quality for Biomedical Technologies VIII, 93150V (11 March 2015); https://doi.org/10.1117/12.2083037

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KEYWORDS

Computed tomography

Arteries

Diagnostics

Ischemia

Blood

Statistical analysis

Blood circulation

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