The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm

Vivian W. Hou; Chenying Yang; Leonard Y. Nelson; Eric J. Seibel

doi:10.1117/12.2040167

3 March 2014 The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm

Vivian W. Hou, Chenying Yang, Leonard Y. Nelson, Eric J. Seibel

Author Affiliations +

Proceedings Volume 8945, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI; 894506 (2014) https://doi.org/10.1117/12.2040167
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Previously we developed an ultrathin, flexible, multimodal scanning fiber endoscope (SFE) for concurrent white light and fluorescence imaging. Autofluorescence (AF) arising from endogenous fluorophores (primarily collagen in the esophagus) act as major confounders in fluorescence-aided detection. To address the issue of AF, a real-time mitigation algorithm was developed and has been show to successfully remove AF during SFE imaging. To test our algorithm, we previously developed flexible, color-matched, synthetic phantoms featuring a homogenous distribution of collagen. In order to more rigorously test the AF mitigation algorithm, a phantom that better mimicked the in-vivo distribution of collagen in tissue was developed.

Citation Download Citation

Vivian W. Hou, Chenying Yang, Leonard Y. Nelson, and Eric J. Seibel "The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm", Proc. SPIE 8945, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI, 894506 (3 March 2014); https://doi.org/10.1117/12.2040167

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Atrial fibrillation

Collagen

Algorithm development

Tissues

Esophagus

Luminescence

Detection and tracking algorithms

Show All Keywords

Keywords/Phrases

Search In:

Publication Years