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We developed a heat-sensitive microbubble (HSM) agent for intraoperative assessment of
thermal ablation margins in cancer ablation therapies. The HSM agent, comprising a core
of liquid perfluorocarbon (PFC) compound and a shell of biodegradable poly lactic-coglycolic
acid (PLGA), was fabricated using an emulsion evaporation method. In our
previous study, significant increase of ultrasound contrast was observed after heat
activation of HSMs. In this study, intraoperative ultrasonic assessment of thermal
ablation margins by HSMs was demonstrated in vivo in a pig model. HSMs were
delivered to the pig liver by portal vein injection. Liver ablation was done using a RF
ablation probe. Intraoperative ultrasound imaging with HSMs clearly delineated the
ablation margin. Fluorescence images of liver tissue samples confirmed the existence and
activation of HSMs. This result demonstrated that the HSM agent can be potentially
utilized as a multimodal contrast agent for intraoperative ultrasonic and fluorescence
assessment of thermal ablation margins in cancer ablation therapies.
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Jiwei Huang, Jeff S. Xu, Carl Schmidt, Ronald X. Xu, "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin," Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 821604 (14 February 2012); https://doi.org/10.1117/12.907110