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11 February 2011 The influence of selected antimicrobial peptides on the physiology of the immune system
Karolina Golab, Anja Mittag, Arkadiusz Pierzchalski, Jozsef Bocsi, Wojciech Kamysz, Attila Tarnok
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Proceedings Volume 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX; 790214 (2011) https://doi.org/10.1117/12.876485
Event: SPIE BiOS, 2011, San Francisco, California, United States
Abstract
Antimicrobial peptides (AMPs) are an essential part of the innate immune system that serves as a first line of defense against invading pathogens. Recently, immunomodulatory activities of AMPs have begun to be appreciated, implying the usefulness of AMPs in the treatment of infectious disease. The aim of this strategy is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Although AMPs could be used as therapeutic agents, a more detailed understanding of how they affect host cells is needed. Hence, several AMPs have been investigated for their potential as a new class of antimicrobial drugs in this study. Synthetic AMPs and AMPs of natural origin were tested on human leukocytes by flow cytometry. Dose- and time-dependent cytotoxic effects could be observed by propidium iodide staining. Different leukocyte subtypes seem to be susceptible to AMP treatment while others were not affected, even in high concentrations. In conclusion, AMPs have an impact on host immune cells. However, their role in stimulation of chemokine production and enhanced leukocyte recruitment remains a crucial aspect and further studies are needed.
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Karolina Golab, Anja Mittag, Arkadiusz Pierzchalski, Jozsef Bocsi, Wojciech Kamysz, and Attila Tarnok "The influence of selected antimicrobial peptides on the physiology of the immune system", Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 790214 (11 February 2011); https://doi.org/10.1117/12.876485
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KEYWORDS
Amplifiers
Flow cytometry
Bacteria
Pathogens
Physiology
Therapeutic agents
Antimicrobial agents
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