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6 March 2023 Point-of-care device for rapid phenotypic antibiotic susceptibility testing using pathogen autofluorescence
Keerthana S., Krishna Sree S., Harish Kumar D., Mohamed Irfan, Jagdish A. Krishnaswamy, Bala Pesala, Geethanjali Radhakrishnan
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Proceedings Volume PC12369, Optics and Biophotonics in Low-Resource Settings IX; PC1236908 (2023) https://doi.org/10.1117/12.2653178
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Anti-microbial resistance has emerged as a major global threat. Due to lack of rapid AST tests, generic antibiotics are typically prescribed. Pathogens possess various metabolic biomarkers such as NAD(P)H and flavins which exhibit auto fluorescence. A rapid phenotypic point-of-care AST device is developed that leverages the changes in the autofluorescence when the pathogens encounter antibiotic stress. The device is integrated with multiple wavelength sources to excite various biomarkers, and a CMOS camera integrated with optical filters to capture the emitted autofluorescence intensity. The results show that the device is capable of determining antibiotic susceptibility with its significant minimum inhibitory concentration in under 5 hours suitable for point-of-care testing.
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Keerthana S., Krishna Sree S., Harish Kumar D., Mohamed Irfan, Jagdish A. Krishnaswamy, Bala Pesala, and Geethanjali Radhakrishnan "Point-of-care device for rapid phenotypic antibiotic susceptibility testing using pathogen autofluorescence", Proc. SPIE PC12369, Optics and Biophotonics in Low-Resource Settings IX, PC1236908 (6 March 2023); https://doi.org/10.1117/12.2653178
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KEYWORDS
Point-of-care devices
Pathogens
Bacteria
Resistance
CMOS cameras
Medicine
Optical filters
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