Fluctuation correlation spectroscopy of near-field trapped nanoparticles

Tiberiu-Dan Onuta; William L. Schaich; Bogdan G. Dragnea

doi:10.1117/12.591679

14 March 2005 Fluctuation correlation spectroscopy of near-field trapped nanoparticles

Tiberiu-Dan Onuta, William L. Schaich, Bogdan G. Dragnea

Proceedings Volume 5736, Nanomanipulation with Light; (2005) https://doi.org/10.1117/12.591679
Event: Integrated Optoelectronic Devices 2005, 2005, San Jose, California, United States

Abstract

A new technique, the near-field correlation spectroscopy (NFCS), is introduced which will be useful for monitoring individual binding events between the biomolecular complex precursors and a functionalized nanoparticle core in a physiological fluid. From jumps in the measured correlation times of single particles trapped in nanoapertures in a metal film, one will be able to determine the rate of binding/dissociation events and, most importantly, the nature of the binding entity, for e.g. discriminate the arrival and binding of a pentamer from a hexamer of protein subunits. This report deals only with the initial steps that are required to implement the new technique.

Citation Download Citation

Tiberiu-Dan Onuta, William L. Schaich, and Bogdan G. Dragnea "Fluctuation correlation spectroscopy of near-field trapped nanoparticles", Proc. SPIE 5736, Nanomanipulation with Light, (14 March 2005); https://doi.org/10.1117/12.591679

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