Functional imaging of cat primary visual cortex with optical coherence tomography

Uma Maheswari Rajagopalan; Hideyuki Takaoka; Ryota Homma; Hirofumi Kadono; Manabu Tanifuji

doi:10.1117/12.470474

14 June 2002 Functional imaging of cat primary visual cortex with optical coherence tomography

Uma Maheswari Rajagopalan, Hideyuki Takaoka, Ryota Homma, Hirofumi Kadono, Manabu Tanifuji

Proceedings Volume 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI; (2002) https://doi.org/10.1117/12.470474
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

We report the application of Optical coherence tomography (OCT) for visualizing a one dimensional depth resolved functional structure of cat brain in vivo. The OCT system is based on the known fact that neural activation induces structural changes such as capillary dilation and cellular swelling. Detecting these changes as an amplitude change of the scattered light, an OCT signal reflecting neural activity i.e., fOCT (functional OCT) could be obtained. Experiments have been done to obtain a depth resolved stimulus-specific profile of activation in cat visual cortex. Our results in one dimension indicate that indeed an orientation dependent functional signal could be obtained. Further, we show that this depth resolved fOCT signal is well correlated with the stimulus dependent column determined by OISI. Based on the results, the smallest functional unit in depth, resolved by the proposed system is around 40 micrometers . We are extending our system to perform two dimensional functional imaging.

Citation Download Citation

Uma Maheswari Rajagopalan, Hideyuki Takaoka, Ryota Homma, Hirofumi Kadono, and Manabu Tanifuji "Functional imaging of cat primary visual cortex with optical coherence tomography", Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); https://doi.org/10.1117/12.470474

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