X-ray monitoring of laser interstitial thermotherapy (LITT) in ex-vivo porcine tissue

Ahmed M. Minhaj; Fabrice Manns; Peter J. Milne; David B. Denham; Nelson Salas Jr.; Jean-Marie A. Parel; David S. Robinson M.D.

doi:10.1117/12.427841

21 May 2001 X-ray monitoring of laser interstitial thermotherapy (LITT) in ex-vivo porcine tissue

Ahmed M. Minhaj, Fabrice Manns, Peter J. Milne, David B. Denham, Nelson Salas Jr., Jean-Marie A. Parel, David S. Robinson M.D.

Author Affiliations +

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427841
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Experiments on the feasibility of x-ray monitoring of laser interstitial thermotherapy (LITT) of breast cancer are presented. Digital images of heated tissue phantoms (including fatty porcine tissue and polyacrylamide/acrylate hydrogel), obtained from an x-ray stereotactic biopsy system, were analyzed for changes in pixel intensity. Tissue phantoms were heated either by a 980 nm diode laser or by resistive heating elements in a custom-made chamber. Analysis was conducted by evaluating the changes in average pixel intensity of regions of interest. Image constancy and stability of the x-ray system were also investigated. Slight changes (less than 5%) dependent on the temperature of the tissue phantom were observed, while changes caused by heat- induced tissue displacement and/or shrinkage were more significant (greater than 10%).

Citation Download Citation

Ahmed M. Minhaj, Fabrice Manns, Peter J. Milne, David B. Denham, Nelson Salas Jr., Jean-Marie A. Parel, and David S. Robinson M.D. "X-ray monitoring of laser interstitial thermotherapy (LITT) in ex-vivo porcine tissue", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427841

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