Onco-hematological diagnostics by IR spectroscopy

Sergey D. Darchuk; Larisa A. Korovina; Fiodor F. Sizov; Vladimir G. Bebeshko

doi:10.1117/12.327999

26 October 1998 Onco-hematological diagnostics by IR spectroscopy

Sergey D. Darchuk, Larisa A. Korovina, Fiodor F. Sizov, Vladimir G. Bebeshko

Proceedings Volume 3436, Infrared Technology and Applications XXIV; (1998) https://doi.org/10.1117/12.327999
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1998, San Diego, CA, United States

Abstract

Application of the infrared (IR) spectroscopy to early medical onco-hematological diagnostics, in particular to leukemia, is described. Leukemia is characterized by the orthophosphates acid (soluble) forms (HPO₄^2-) accumulation in bone apatites. Bone hydroxyapatite contains predominantly basic PO₄^3- nonsoluble orthophosphate. At the same time condensed forms of pyrophosphates (e.g., CaH₂P₃O₇) in bones and especially in dried urine were found by the analysis of IR absorption spectra of persons with leukemia. It was show that the dried urine infrared quantitative absorption spectra investigations of phosphates contents make it possible to trace the dynamics of these elements contents during the leukemia progression and can serve for onco-hematological diagnostics at early stage of leukemia.

Citation Download Citation

Sergey D. Darchuk, Larisa A. Korovina, Fiodor F. Sizov, and Vladimir G. Bebeshko "Onco-hematological diagnostics by IR spectroscopy", Proc. SPIE 3436, Infrared Technology and Applications XXIV, (26 October 1998); https://doi.org/10.1117/12.327999

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