Laser-induced stress transients: aqueous pores of membranes

Thomas J. Flotte M.D.; Shun Lee; Hong Zhang; Daniel J. McAuliffe Sr.; Jeremy Taitelbaum; Apostolos George Doukas

doi:10.1117/12.239569

7 May 1996 Laser-induced stress transients: aqueous pores of membranes

Thomas J. Flotte M.D., Shun Lee, Hong Zhang, Daniel J. McAuliffe Sr., Jeremy Taitelbaum, Apostolos George Doukas

Proceedings Volume 2681, Laser-Tissue Interaction VII; (1996) https://doi.org/10.1117/12.239569
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Lasers can be used to enhance the delivery of a number of molecules. The model that best fits our data is for the formation of aqueous pores. These pores are present for up to 80 seconds. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Citation Download Citation

Thomas J. Flotte M.D., Shun Lee, Hong Zhang, Daniel J. McAuliffe Sr., Jeremy Taitelbaum, and Apostolos George Doukas "Laser-induced stress transients: aqueous pores of membranes", Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); https://doi.org/10.1117/12.239569

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