Discriminating the size and density of objects within tissue: frequency-domain versus steady-state measurements

Steven L. Jacques; Andreas H. Hielscher

doi:10.1117/12.209971

30 May 1995 Discriminating the size and density of objects within tissue: frequency-domain versus steady-state measurements

Steven L. Jacques, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation; (1995) https://doi.org/10.1117/12.209971
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Steady-state (SS) optical measurements are simpler and less expensive than frequency-domain (FD) measurements. So why bother with FD? This paper illustrates the advantage obtained by FD vs. SS, using computer simulated experiments. A single shperical object is placed in the center of our model for the human prostate. The object is given a range of sized and values for its incremental absorption ((Delta) (mu) _a) above the background medium (bloodless prostate), with the condition that the optical volume (equals object volume X (Delta) (mu) _a) remains constant. Simulations of SS measurements and FD measurements using a 3 GHz modulation frequency were conducted and two measurements simulated: the frequency difference ((Delta) P equals phase with object--phase without object) and the relative amplitude (A/A₀ equals amplitude with object/amplitude without object). The results show that A/A₀ at SS and 3 GHz are very similar in their response to the object size, and the (Delta) P at 3 GHz offered important additional information.

Citation Download Citation

Steven L. Jacques and Andreas H. Hielscher "Discriminating the size and density of objects within tissue: frequency-domain versus steady-state measurements", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); https://doi.org/10.1117/12.209971

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