Development of a K-edge micro CT for the study of tumor angiogenesis in small animals

G. Baldazzi; D. Bollini; M. Gambaccini; R. Golfieri; P. L. Lollini; A. Margotti; S. Masetti; G. Nicoletti; G. Pancaldi; L. Roma; P. L. Rossi; M. Zuffa

doi:10.1117/12.651311

2 March 2006 Development of a K-edge micro CT for the study of tumor angiogenesis in small animals

G. Baldazzi, D. Bollini, M. Gambaccini, R. Golfieri, P. L. Lollini, A. Margotti, S. Masetti, G. Nicoletti, G. Pancaldi, L. Roma, P. L. Rossi, M. Zuffa

Author Affiliations +

Proceedings Volume 6142, Medical Imaging 2006: Physics of Medical Imaging; 614241 (2006) https://doi.org/10.1117/12.651311
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

A new micro scanner CT for small animals - based on a couple of parallel quasi-monochromatic X-ray beams with different energies selectable - is under development. The aim of the study is the in vivo imaging of the tumor neo-angiogenesis pattern in an earlier diagnostic phase and the analysis of cancer growth and metastasis development in different tumor types on mice. As previously demonstrated¹, the imaging system based on dual energy quasi- monochromatic X-ray beams provides higher sensitivity in detecting low concentrations of iodine contrast medium if compared to traditional polychromatic X-ray equipment. The K-edge dual energy radiology is a realistic candidate to recognize tumor neo- angiogenesis process in a very earlier stage, in which conventional systems are very poor in sensitivity. Moreover, the capability to select the energy of quasi-monochromatic beams enables the use of the Multi-Energy Quasi-Monochromatic technique. Tuning properly the energies allows maximizing the difference between linear absorption coefficients of healthy and pathological tissues increasing the contrast of pathologies. In order to optimize the contrast with this technique, one should know the X-ray energy regions where the absorption of healthy and pathological tissues eventually differs and that for each type of tumor under study. For this reason, the systematic X-ray characterization of many types of healthy and neoplastic human and mice tissues is in progress. The goal of this work is to obtain a catalog of liner attenuation coefficients of a variety of pathological tissues for respect to the healthy ones, finding any energy windows of radiological differentiation. In this paper, the theoretical methods are presented with development works and preliminary results.

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G. Baldazzi, D. Bollini, M. Gambaccini, R. Golfieri, P. L. Lollini, A. Margotti, S. Masetti, G. Nicoletti, G. Pancaldi, L. Roma, P. L. Rossi, and M. Zuffa "Development of a K-edge micro CT for the study of tumor angiogenesis in small animals", Proc. SPIE 6142, Medical Imaging 2006: Physics of Medical Imaging, 614241 (2 March 2006); https://doi.org/10.1117/12.651311

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