Improved photosensitizers for photodynamic therapy

Ravindra K. Pandey; Fuu-Yau Shiau; Isabelle Meunier; Subbaraya Ramaprasad; Adam B. Sumlin; Thomas J. Dougherty; Kevin M. Smith

doi:10.1117/12.60948

1 June 1992 Improved photosensitizers for photodynamic therapy

Ravindra K. Pandey, Fuu-Yau Shiau, Isabelle Meunier, Subbaraya Ramaprasad, Adam B. Sumlin, Thomas J. Dougherty, Kevin M. Smith

Author Affiliations +

Proceedings Volume 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy; (1992) https://doi.org/10.1117/12.60948
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

In order to evaluate the effect of substituents in photosensitizing activity, a series of long wavelength absorbing photosensitizers related to pyropheophorbides, bacteriopheophorbides, and benzoporphyrin derivatives were synthesized. Pheophorbide dimers, covalently joining two molecules of pyropheophorbide-a and bacteriopheophorbide-a with lysine as a cross-link were also prepared. The syntheses and spectroscopic properties of these compounds are discussed. Some of these compounds were tested for in vivo photosensitizing activity vis-a-vis Photofrin II^TM, using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. The preliminary in vivo results suggest that replacement of substituents at peripheral positions of the macrocycles causes a significant difference in photosensitizing efficacy.

Citation Download Citation

Ravindra K. Pandey, Fuu-Yau Shiau, Isabelle Meunier, Subbaraya Ramaprasad, Adam B. Sumlin, Thomas J. Dougherty, and Kevin M. Smith "Improved photosensitizers for photodynamic therapy", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); https://doi.org/10.1117/12.60948

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