In-vivo NMR studies of deuterium-labeled photosensitizers in mice tumor model

Subbaraya Ramaprasad; Y. H. Liu; R. K. Pandey; Fuu-Yau Shiau; Kevin M. Smith

doi:10.1117/12.146327

18 June 1993 In-vivo NMR studies of deuterium-labeled photosensitizers in mice tumor model

Subbaraya Ramaprasad, Y. H. Liu, R. K. Pandey, Fuu-Yau Shiau, Kevin M. Smith

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146327
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Photodynamic therapy (PDT) has emerged as a promising modality for the treatment of cancer. We are using newly synthesized and chemically defined and characterized porphyrin photosensitizers that are specifically labeled with deuterium to perform in vivo NMR studies in a murine tumor model. In vivo magnetic resonance offers the potential for repetitive, safe, noninvasive evaluation of photosensitizers, tumor metabolism, and the effect of PDT on the tumor metabolism. In an effort to monitor noninvasively the photosensitizers in an in vivo tumor model, we are synthesizing several deuterium labeled photosensitizers which absorb red light at or above 630 nm. Development of methods to test these photosensitizers directly in humans is not feasible at this time, since these photosensitizers are new and we do not yet understand the side effects. In addition, we do not understand the potential benefits compared with Photofrin II, the widely used photosensitizer. To perform our in vivo deuterium NMR studies on mouse foot tumors, we have constructed a solenoid coil which operates at 30.7 MHz for the deuterium nucleus. We have been able to detect the deuterium labeled photosensitizer in the tumor after a direct intra-tumor injection. The use of ³¹P NMR to predict the possible outcome of PDT in these tumors is also discussed.

Citation Download Citation

Subbaraya Ramaprasad, Y. H. Liu, R. K. Pandey, Fuu-Yau Shiau, and Kevin M. Smith "In-vivo NMR studies of deuterium-labeled photosensitizers in mice tumor model", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146327

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KEYWORDS

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Photodynamic therapy

In vivo imaging

Spectroscopy

Absorption

Mode conditioning cables

Tumor growth modeling

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